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Calcineurin-inhibitor induced pain syndrome (CIPS): a severe disabling complication after organ transplantation.

  • Academic Journal
  • Grotz WH; Department of Nephrology, Medizinische Universit√§tsklinik, University of Freiburg, Germany. Grotz@med1.ukl.uni-freiburg.de
    Breitenfeldt MK
    Braune SW
    Allmann KH
    Krause TM
    Rump JA
    Schollmeyer PJ
  • Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2001; Vol. 14 (1), pp. 16-23.
  • English
  • Bone pain after transplantation is a frequent complication that can be caused by several diseases. Treatment strategies depend on the correct diagnosis of the pain. Nine patients with severe pain in their feet, which was registered after transplantation, were investigated. Bone scans showed an increased tracer uptake of the foot bones. Magnetic resonance imaging demonstrated bone marrow oedema in the painful bones. Pain was not explained by other diseases causing foot pain, like reflex sympathetic dystrophy, polyneuropathy, Morton's neuralgia, gout, osteoporosis, avascular necrosis, intermittent claudication, orthopaedic foot deformities, stress fractures, and hyperparathyroidism. The reduction of cyclosporine- or tacrolimus trough levels and the administration of calcium channel blockers led to relief of pain. The Calcineurin-inhibitor Induced Pain Syndrome (CIPS) is a rare but severe side effect of cyclosporine or tacrolimus and is accurately diagnosed by its typical presentation, magnetic resonance imaging and bone scans. Incorrect diagnosis of the syndrome will lead to a significant reduction of life quality in patients suffering from CIPS.
Additional Information
Publisher: Blackwell Pub Country of Publication: England NLM ID: 8908516 Publication Model: Print Cited Medium: Print ISSN: 0934-0874 (Print) Linking ISSN: 09340874 NLM ISO Abbreviation: Transpl Int Subsets: MEDLINE
Publication: 2005- : Oxford : Blackwell Pub.
Original Publication: [Heidelberg, FRG] : Springer International, 1988-
0 (Calcineurin Inhibitors)
0 (Enzyme Inhibitors)
83HN0GTJ6D (Cyclosporine)
WM0HAQ4WNM (Tacrolimus)
Date Created: 20010327 Date Completed: 20010614 Latest Revision: 20190915
20220302
10.1007/s001470000285
11263551

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