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Academic Journal
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van Dongen KCW; Division of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
Ioannou A; Laboratory of Microbiology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
Wesseling S; Division of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
Beekmann K; Wageningen Food Safety Research, Wageningen University and Research, Akkermaalsbos 2, 6708 WB, Wageningen, The Netherlands.
Belzer C; Laboratory of Microbiology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands. -
FEMS microbiology ecology [FEMS Microbiol Ecol] 2022 Dec 14; Vol. 99 (1).
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English
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The Amadori product fructoselysine is formed upon heating of food products and is abundantly present in infant formula while being almost absent in breast milk. The human gut microbiota can degrade fructoselysine for which interindividual differences have been described for adults. The aim of this study is to compare functional differences in microbial fructoselysine degradation between breast-fed and formula-fed infants, in view of their different diets and resulting different fructoselysine exposures. First, a publicly available metagenomic dataset with metagenome-assembled genomes (MAGs) from infant fecal samples was analyzed and showed that query genes involved in fructoselysine degradation (frlD/yhfQ) were abundantly present in multiple bacterial taxa in the fecal samples, with a higher prevalence in the formula-fed infants. Next, fecal samples collected from exclusively breast-fed and formula-fed infants were anaerobically incubated with fructoselysine. Both groups degraded fructoselysine, however the fructoselysine degradation activity was significantly higher by fecal samples from formula-fed infants. Overall, this study provides evidence that infant formula feeding, leading to increased dietary fructoselysine exposure, seems to result in an increased fructoselysine degradation activity in the gut microbiota of infants. This indicates that the infant gut microbiota adapts towards dietary fructoselysine exposure.
(© The Author(s) 2022. Published by Oxford University Press on behalf of FEMS.)
Additional Information
Publisher: Oxford University Press Country of Publication: England NLM ID: 8901229 Publication Model: Print Cited Medium: Internet ISSN: 1574-6941 (Electronic) Linking ISSN: 01686496 NLM ISO Abbreviation: FEMS Microbiol Ecol Subsets: MEDLINE
Publication: 2015- : Oxford Oxford University Press
Original Publication: [Amsterdam] : Elsevier Science Publishers on behalf of the Federation of European Microbiological Societies, [1985-
Original Publication: [Amsterdam] : Elsevier Science Publishers on behalf of the Federation of European Microbiological Societies, [1985-
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PLoS One. 2013 Apr 22;8(4):e61217. (PMID: 23630581)
Anal Chim Acta. 2008 Jun 9;617(1-2):85-96. (PMID: 18486644)
PLoS One. 2020 Jan 15;15(1):e0227285. (PMID: 31940382)
Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6. (PMID: 23193283)
Nucleic Acids Res. 2021 Jul 2;49(W1):W293-W296. (PMID: 33885785)
Mol Nutr Food Res. 2014 Jul;58(7):1552-60. (PMID: 24867162)
J Biol Chem. 2002 Nov 8;277(45):42523-9. (PMID: 12147680)
Toxicol In Vitro. 2021 Apr;72:105078. (PMID: 33429044)
Food Chem. 2022 Jan 1;366:130601. (PMID: 34298391)
Nucleic Acids Res. 2022 Jan 7;50(D1):D785-D794. (PMID: 34520557)
Crit Rev Food Sci Nutr. 1994;34(4):321-69. (PMID: 7945894)
Genome Biol. 2011 Jun 24;12(6):R60. (PMID: 21702898)
Nature. 2019 Apr;568(7753):505-510. (PMID: 30867587)
J Mol Biol. 1990 Oct 5;215(3):403-10. (PMID: 2231712)
Food Chem. 2017 Apr 15;221:1895-1903. (PMID: 27979178)
PLoS One. 2013;8(2):e57923. (PMID: 23460914)
Pediatr Allergy Immunol. 2014 Aug;25(5):428-38. (PMID: 24899389)
J Agric Food Chem. 2007 Feb 7;55(3):723-7. (PMID: 17263466)
Sci Rep. 2021 Jan 21;11(1):1472. (PMID: 33479326)
Cell Host Microbe. 2015 May 13;17(5):690-703. (PMID: 25974306)
Sci Rep. 2020 Sep 25;10(1):15792. (PMID: 32978424)
Front Genet. 2020 Jan 23;10:1366. (PMID: 32117417)
Nahrung. 2001 Jun;45(3):177-81. (PMID: 11455784)
FEBS Lett. 2004 Nov 19;577(3):469-72. (PMID: 15556630)
Mol Biol Evol. 2008 Jul;25(7):1307-20. (PMID: 18367465)
Clin Nutr. 2021 May;40(5):3019-3031. (PMID: 33509667)
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Keywords: in vitro model; AGEs; adaptation; blastp; infant formula; infant gut microbiota; metagenome-assembled genomes
21291-40-7 (fructosyl-lysine)
Date Created: 20221128 Date Completed: 20221216 Latest Revision: 20230206
20230206
PMC9749803
10.1093/femsec/fiac145
36442156