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DNA polymorphisms amplified by arbitrary primers are useful as genetic markers.

  • Academic Journal
  • Williams JG; Central Research and Development Department, E.I. du Pont de Nemours & Co., Inc, Wilmington, DE 19880.
    Kubelik AR
    Livak KJ
    Rafalski JA
    Tingey SV
  • Nucleic acids research [Nucleic Acids Res] 1990 Nov 25; Vol. 18 (22), pp. 6531-5.
  • English
  • Molecular genetic maps are commonly constructed by analyzing the segregation of restriction fragment length polymorphisms (RFLPs) among the progeny of a sexual cross. Here we describe a new DNA polymorphism assay based on the amplification of random DNA segments with single primers of arbitrary nucleotide sequence. These polymorphisms, simply detected as DNA segments which amplify from one parent but not the other, are inherited in a Mendelian fashion and can be used to construct genetic maps in a variety of species. We suggest that these polymorphisms be called RAPD markers, after Random Amplified Polymorphic DNA.
Additional Information
Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Print ISSN: 0305-1048 (Print) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Publication: 1992- : Oxford : Oxford University Press
Original Publication: London, Information Retrieval ltd.
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0 (Genetic Markers)
9007-49-2 (DNA)
Date Created: 19901125 Date Completed: 19910115 Latest Revision: 20190501

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