scroll to top
0

EBSCO Auth Banner

Let's find your institution. Click here.

Environmental endocrine disruptors: Effects on the human male reproductive system.

  • Academic Journal
  • Sweeney MF; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, 02111, USA.
    Hasan N; Program in Cell, Molecular & Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, 02111, USA.
    Soto AM; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, 02111, USA.; Program in Cell, Molecular & Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, 02111, USA.; Department of Integrative Physiology & Pathobiology, Tufts University, 136 Harrison Ave, Boston, MA, 02111, USA.
    Sonnenschein C; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, 02111, USA. carlos.sonnenschein@tufts.edu.; Program in Cell, Molecular & Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, 02111, USA. carlos.sonnenschein@tufts.edu.; Department of Integrative Physiology & Pathobiology, Tufts University, 136 Harrison Ave, Boston, MA, 02111, USA. carlos.sonnenschein@tufts.edu.
  • Reviews in endocrine & metabolic disorders [Rev Endocr Metab Disord] 2015 Dec; Vol. 16 (4), pp. 341-57.
  • English
  • Incidences of altered development and neoplasia of male reproductive organs have increased during the last 50 years, as shown by epidemiological data. These data are associated with the increased presence of environmental chemicals, specifically "endocrine disruptors," that interfere with normal hormonal action. Much research has gone into testing the effects of specific endocrine disrupting chemicals (EDCs) on the development of male reproductive organs and endocrine-related cancers in both in vitro and in vivo models. Efforts have been made to bridge the accruing laboratory findings with the epidemiological data to draw conclusions regarding the relationship between EDCs, altered development and carcinogenesis. The ability of EDCs to predispose target fetal and adult tissues to neoplastic transformation is best explained under the framework of the tissue organization field theory of carcinogenesis (TOFT), which posits that carcinogenesis is development gone awry. Here, we focus on the available evidence, from both empirical and epidemiological studies, regarding the effects of EDCs on male reproductive development and carcinogenesis of endocrine target tissues. We also critique current research methodology utilized in the investigation of EDCs effects and outline what could possibly be done to address these obstacles moving forward.
Additional Information
Publisher: Springer Country of Publication: Germany NLM ID: 100940588 Publication Model: Print Cited Medium: Internet ISSN: 1573-2606 (Electronic) Linking ISSN: 13899155 NLM ISO Abbreviation: Rev Endocr Metab Disord Subsets: MEDLINE
Publication: 2005-: Heidelberg : Springer
Original Publication: Boston : Kluwer Academic Publishers, c2000-
Bioessays. 2011 May;33(5):332-40. (PMID: 21503935)
Biol Reprod. 2011 Jun;84(6):1094-102. (PMID: 21270426)
J Urol. 2000 Mar;163(3):951-6. (PMID: 10688029)
Science. 1975 Dec 5;190(4218):991-2. (PMID: 242076)
Mol Reprod Dev. 2002 Dec;63(4):510-7. (PMID: 12412054)
Int J Androl. 2008 Apr;31(2):288-93. (PMID: 17971158)
Reprod Toxicol. 2007 Apr-May;23(3):366-73. (PMID: 17258888)
Int J Androl. 2004 Oct;27(5):282-90. (PMID: 15379968)
Am J Epidemiol. 2013 Jan 1;177(1):59-74. (PMID: 23171882)
Breast Cancer Res. 2008;10(1):201. (PMID: 18226174)
Biol Reprod. 2001 Oct;65(4):1215-23. (PMID: 11566746)
Environ Health Perspect. 1997 Jan;105(1):70-6. (PMID: 9074884)
J Natl Cancer Inst. 1973 Nov;51(5):1637-46. (PMID: 4128486)
J Cell Physiol. 2014 Mar;229(3):271-6. (PMID: 24037862)
Wiley Interdiscip Rev Syst Biol Med. 2010 Nov-Dec;2(6):734-41. (PMID: 20890968)
Reprod Toxicol. 2001 Nov-Dec;15(6):647-63. (PMID: 11738518)
Matrix Biol. 2004 Aug;23(5):323-9. (PMID: 15464364)
Prostate. 2015 Feb;75(2):126-40. (PMID: 25327291)
Carcinogenesis. 2015 Jun;36 Suppl 1:S232-53. (PMID: 26106141)
Phys Biol. 2011 Apr;8(2):026013. (PMID: 21441648)
Endocr Rev. 2012 Jun;33(3):378-455. (PMID: 22419778)
Hum Reprod. 2012 May;27(5):1451-9. (PMID: 22402212)
J Natl Cancer Inst. 2014 Mar;106(3):djt465. (PMID: 24552677)
Toxicol Appl Pharmacol. 2004 Apr 1;196(1):149-55. (PMID: 15050416)
Reprod Toxicol. 2012 Dec;34(4):498-503. (PMID: 22841741)
Biol Reprod. 2012 May;86(5):135, 1-12. (PMID: 22302688)
Reproduction. 2011 Feb;141(2):207-16. (PMID: 21062904)
Dev Dyn. 2005 Aug;233(4):1272-86. (PMID: 15986456)
N Engl J Med. 2013 Sep 12;369(11):1011-22. (PMID: 24024838)
Cancer Res. 1986 May;46(5):2271-5. (PMID: 3697972)
J Comp Pathol. 1996 May;114(4):407-18. (PMID: 8814535)
Int J Dev Biol. 2013;57(2-4):255-63. (PMID: 23784836)
AJR Am J Roentgenol. 2011 Mar;196(3):W247-59. (PMID: 21343472)
J Occup Environ Med. 2004 Mar;46(3):271-9. (PMID: 15091290)
Ecancermedicalscience. 2009;3:140. (PMID: 22276005)
Development. 2013 Aug;140(15):3146-55. (PMID: 23824575)
Psychoneuroendocrinology. 1988;13(4):309-16. (PMID: 3227089)
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2012;47(13):2173-9. (PMID: 22871016)
Cancer Res. 2006 Jun 1;66(11):5624-32. (PMID: 16740699)
Reprod Toxicol. 2011 Apr;31(3):337-43. (PMID: 21055462)
Proc Natl Acad Sci U S A. 2001 May 22;98(11):6330-5. (PMID: 11371645)
Int J Androl. 2006 Feb;29(1):211-8. (PMID: 16466542)
Physiol Rev. 2001 Jul;81(3):1269-304. (PMID: 11427696)
Drug Metab Dispos. 2003 Apr;31(4):384-91. (PMID: 12642463)
Reprod Toxicol. 2013 Jun;37:15-23. (PMID: 23348055)
Endocrinology. 2014 Mar;155(3):805-17. (PMID: 24424067)
Reprod Toxicol. 2016 Jan;59:167-82. (PMID: 26493093)
Tissue Eng Part C Methods. 2014 Jan;20(1):42-51. (PMID: 23675751)
Br J Ophthalmol. 2007 Nov;91(11):1547-50. (PMID: 17591666)
Chemosphere. 1998 Oct-Nov;37(9-12):1627-43. (PMID: 9828293)
World J Urol. 2004 Apr;22(1):2-14. (PMID: 15034740)
Arch Environ Health. 1978 Jan-Feb;33(1):12-5. (PMID: 629591)
Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10185-90. (PMID: 10963680)
Environ Health Perspect. 2005 Aug;113(8):1056-61. (PMID: 16079079)
J Clin Endocrinol Metab. 2002 Nov;87(11):5185-90. (PMID: 12414890)
Reproduction. 2010 Feb;139(2):373-9. (PMID: 19887539)
Vitam Horm. 1975;33:61-102. (PMID: 180681)
Reprod Biol Endocrinol. 2011;9:126. (PMID: 21914226)
Development. 2008 Mar;135(6):995-1003. (PMID: 18296651)
Prostate Cancer Prostatic Dis. 1998 Dec;1(6):289-296. (PMID: 12496869)
Differentiation. 2014 Sep-Oct;88(2-3):51-69. (PMID: 25449352)
Prog Clin Biol Res. 1991;370:249-55. (PMID: 1924456)
J Anat. 1944 Jul;78(Pt 4):130-45. (PMID: 17104953)
Br J Cancer. 1988 Feb;57(2):216-8. (PMID: 3358915)
Endocr Rev. 1987 Aug;8(3):338-62. (PMID: 3308446)
J Steroid Biochem. 1978 Jun;9(6):533-7. (PMID: 692119)
Prostate. 2010 Oct 1;70(14):1600-7. (PMID: 20607766)
Med Oncol. 2014 Mar;31(3):876. (PMID: 24504844)
Cancer Res. 2008 Mar 15;68(6):2024-32. (PMID: 18339885)
Cancer Cell Int. 2014 Nov 30;14(1):113. (PMID: 25493071)
Nat Rev Endocrinol. 2015 Sep;11(9):507-8. (PMID: 26239610)
PLoS One. 2014;9(3):e90332. (PMID: 24594937)
Toxicol Ind Health. 1999 Jan-Mar;15(1-2):48-64. (PMID: 10188191)
Toxicol Sci. 2002 Apr;66(2):216-25. (PMID: 11896288)
Endocr Pract. 2008 May-Jun;14(4):409-11. (PMID: 18558589)
Toxicol Sci. 2000 Mar;54(1):138-53. (PMID: 10746941)
PLoS One. 2013;8(5):e63902. (PMID: 23704952)
Endocr Pract. 2003 Sep-Oct;9(5):370-5. (PMID: 14583418)
Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2056-61. (PMID: 9050904)
Semin Surg Oncol. 1990;6(6):343-6. (PMID: 2263810)
Prostate. 1994;24(2):67-78. (PMID: 7508622)
Endocrinology. 1992 Jun;130(6):3703-14. (PMID: 1597166)
Reprod Toxicol. 2010 Nov;30(3):353-64. (PMID: 20566332)
Birth Defects Res B Dev Reprod Toxicol. 2011 Dec;92(6):526-33. (PMID: 21922642)
PLoS One. 2009;4(5):e5591. (PMID: 19440348)
Environ Health Perspect. 2009 Mar;117(3):309-15. (PMID: 19337501)
Dev Biol. 2015 May 1;401(1):92-102. (PMID: 25576028)
PLoS One. 2012;7(12):e51579. (PMID: 23284716)
Toxicol Sci. 2000 May;55(1):143-51. (PMID: 10788569)
Cancer Biomark. 2008;4(4-5):213-25. (PMID: 18957712)
Nature. 1995 Jun 15;375(6532):581-5. (PMID: 7791873)
J Endocrinol Invest. 2015 Jul;38(7):745-52. (PMID: 25770454)
Natl Toxicol Program Tech Rep Ser. 1982 Mar;215:1-116. (PMID: 12778220)
Reprod Toxicol. 2007 Apr-May;23(3):383-90. (PMID: 17123778)
Toxicol Sci. 2010 Jun;115(2):612-3; author reply 614-20. (PMID: 20164146)
Curr Probl Pediatr Adolesc Health Care. 2007 Feb;37(2):50-72. (PMID: 17223057)
Reprod Toxicol. 2012 Jan;33(1):106-15. (PMID: 22240090)
Endocrinology. 2012 Sep;153(9):4097-110. (PMID: 22733974)
Cancer Lett. 2015 Oct 10;367(1):12-7. (PMID: 26185001)
J Clin Endocrinol Metab. 2007 Jul;92(7):2519-25. (PMID: 17456570)
Environ Health Perspect. 2000 Oct;108(10):961-6. (PMID: 11049816)
Environ Health. 2014;13:118. (PMID: 25533907)
J Clin Endocrinol Metab. 2013 Jun;98(6):2230-8. (PMID: 23569219)
Environ Health. 2015;14:13. (PMID: 25971433)
Endocr Relat Cancer. 2007 Jun;14(2):257-66. (PMID: 17639042)
Environ Health Perspect. 1999 Apr;107(4):297-302. (PMID: 10090709)
Hum Exp Toxicol. 2006 Jul;25(7):369-73. (PMID: 16898165)
Ann N Y Acad Sci. 1991;628:412-8. (PMID: 2069318)
Endocr Rev. 2009 Jun;30(4):293-342. (PMID: 19502515)
Cell Differ. 1984 Dec;15(2-4):69-74. (PMID: 6598576)
Hum Reprod. 2015 Feb;30(2):447-53. (PMID: 25527819)
J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):199-208. (PMID: 23702822)
J Natl Cancer Inst. 2008 May 7;100(9):663-71. (PMID: 18445826)
Endocrinology. 2000 Sep;141(9):3471-7. (PMID: 10965920)
Ann Endocrinol (Paris). 2014 May;75(2):54-7. (PMID: 24793993)
Nat Rev Endocrinol. 2010 Jul;6(7):363-70. (PMID: 20498677)
Cancer Res. 2005 Jan 1;65(1):54-65. (PMID: 15665279)
PPAR Res. 2008;2008:359267. (PMID: 18288285)
Urol Oncol. 2013 Feb;31(2):198-204. (PMID: 21795073)
Toxicol Sci. 2014 May;139(1):174-97. (PMID: 24496637)
J Steroid Biochem Mol Biol. 2006 Nov;101(4-5):263-74. (PMID: 17010603)
PLoS Genet. 2015 Jan;11(1):e1004949. (PMID: 25615633)
Nat Rev Cancer. 2001 Oct;1(1):46-54. (PMID: 11900251)
Nonlinearity Biol Toxicol Med. 2004 Jan;2(1):11-20. (PMID: 19330104)
Front Endocrinol (Lausanne). 2015 May 07;6:58. (PMID: 25999913)
Cancer Res. 1989 Jul 1;49(13):3474-81. (PMID: 2731169)
Best Pract Res Clin Endocrinol Metab. 2006 Mar;20(1):77-90. (PMID: 16522521)
Reprod Toxicol. 2006 Apr;21(3):225-40. (PMID: 16439099)
J Biol Chem. 2013 May 3;288(18):12722-32. (PMID: 23530035)
Pediatrics. 2010 Jan;125(1):e122-9. (PMID: 20008419)
Hum Reprod. 2001 May;16(5):972-8. (PMID: 11331648)
Biol Reprod. 2001 Oct;65(4):1271-7. (PMID: 11566753)
J Am Med Assoc. 1951 May 5;146(1):7-9. (PMID: 14823885)
Environ Health Perspect. 2013 Sep;121(9):1040-6. (PMID: 23876597)
Am J Pathol. 2014 Oct;184(10):2598-607. (PMID: 25088980)
Nature. 1990 Nov 29;348(6300):450-2. (PMID: 2247150)
Eur J Cancer. 1966 Aug;2(3):211-20. (PMID: 5974757)
Drug Metab Dispos. 2006 Sep;34(9):1606-14. (PMID: 16790556)
Vet Pathol. 1991 Mar;28(2):139-45. (PMID: 1676552)
Toxicol Appl Pharmacol. 2015 Aug 1;286(3):159-67. (PMID: 25922126)
J Natl Cancer Inst. 2001 Apr 4;93(7):545-51. (PMID: 11287449)
Arch Dis Child. 2010 Mar;95(3):237-9. (PMID: 20308342)
Nucleic Acids Res. 1991 May 11;19(9):2373-8. (PMID: 2041777)
J Endocrinol. 1986 Sep;110(3):467-70. (PMID: 3639118)
J Natl Cancer Inst. 1988 Sep 7;80(13):1045-53. (PMID: 2457709)
Clin Breast Cancer. 2015 Aug;15(4):245-50. (PMID: 26165199)
Ind Health. 2002 Oct;40(4):375-81. (PMID: 12502241)
Vitam Horm. 2014;94:129-65. (PMID: 24388189)
PLoS One. 2015;10(3):e0122290. (PMID: 25799167)
Sci Transl Med. 2015 Jan 7;7(269):269ra2. (PMID: 25568070)
Occup Environ Med. 2015 Nov;72(11):805-11. (PMID: 26304777)
Cancer Causes Control. 2013 Sep;24(9):1757-61. (PMID: 23775027)
Proc Natl Acad Sci U S A. 1988 Nov;85(21):8151-5. (PMID: 3186717)
Mol Cell Endocrinol. 2014 Dec;398(1-2):101-13. (PMID: 25304273)
Endocrinology. 2007 Jan;148(1):116-27. (PMID: 17023525)
Environ Health Perspect. 1995 Sep;103(9):844-50. (PMID: 7498097)
PLoS One. 2010;5(9). pii: e13100. doi: 10.1371/journal.pone.0013100. (PMID: 20927350)
Basic Clin Pharmacol Toxicol. 2010 Feb;106(2):118-23. (PMID: 19912166)
Pflugers Arch. 2008 Apr;456(1):51-60. (PMID: 18172604)
Int J Dev Biol. 2013;57(2-4):225-39. (PMID: 23784834)
Toxicol Ind Health. 1999 Jan-Mar;15(1-2):12-25. (PMID: 10188188)
Cancer Cell. 2005 Sep;8(3):241-54. (PMID: 16169468)
J Cell Sci. 2004 Mar 15;117(Pt 8):1495-502. (PMID: 14996910)
Environ Health Perspect. 1996 Aug;104 Suppl 4:741-803. (PMID: 8880001)
PLoS One. 2012;7(4):e34158. (PMID: 22496781)
Basic Clin Pharmacol Toxicol. 2008 Feb;102(2):134-8. (PMID: 18226066)
Environ Health Perspect. 2008 Feb;116(2):149-57. (PMID: 18288311)
Environ Sci Technol. 2002 Apr 15;36(8):1751-6. (PMID: 11993873)
Toxicol Appl Pharmacol. 2002 Aug 15;183(1):10-22. (PMID: 12217638)
PLoS One. 2014;9(4):e93325. (PMID: 24691468)
Obstet Gynecol. 1980 Nov;56(5):537-42. (PMID: 7432722)
Dose Response. 2013 Oct 07;12(2):259-76. (PMID: 24910584)
Toxicol Sci. 2006 May;91(1):93-103. (PMID: 16443925)
Reprod Toxicol. 2014 Jan;43:56-66. (PMID: 24257414)
JAMA. 2014 Mar 19;311(11):1143-9. (PMID: 24643604)
Reprod Toxicol. 2009 Nov;28(3):342-53. (PMID: 19383540)
Environ Health Perspect. 2006 Oct;114(10):1508-14. (PMID: 17035134)
Lancet. 1993 May 29;341(8857):1392-5. (PMID: 8098802)
Environ Health Perspect. 1993 Oct;101(5):378-84. (PMID: 8080506)
Environ Health. 2015;14:74. (PMID: 26376727)
Birth Defects Res A Clin Mol Teratol. 2011 Oct;91(10):867-72. (PMID: 21987463)
Dev Biol. 2001 May 1;233(1):1-12. (PMID: 11319853)
Dev Biol. 2004 Jun 1;270(1):1-18. (PMID: 15136137)
J Anat. 1997 May;190 ( Pt 4):577-88. (PMID: 9183680)
Endocrinology. 2009 Dec;150(12):5575-85. (PMID: 19819939)
Int J Cancer. 2006 Jun 15;118(12):3099-111. (PMID: 16395710)
Acta Pathol Microbiol Scand. 1956;39(4):255-67. (PMID: 13381470)
R01 ES008314 United States ES NIEHS NIH HHS; R01ES08314 United States ES NIEHS NIH HHS
Keywords: Carcinogenesis; Developmental origins of adult disease; Endocrine disruption; Male breast cancer; Male reproduction; Prostate cancer; Testicular cancer; Tissue organization field theory
0 (Endocrine Disruptors)
0 (Environmental Pollutants)
Date Created: 20160206 Date Completed: 20161104 Latest Revision: 20181113
20221216
PMC4803593
10.1007/s11154-016-9337-4
26847433
sponsored