Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine.

Publication Type:
Academic Journal
Author(s):
van Dongen KCW; Division of Toxicology, Wageningen University and Research, P.O. Box 8000, Wageningen 6700 EA, The Netherlands.
Belzer C; Laboratory of Microbiology, Wageningen University and Research, P.O. Box 8033, Wageningen 6700 EH, The Netherlands.
Bakker W; Division of Toxicology, Wageningen University and Research, P.O. Box 8000, Wageningen 6700 EA, The Netherlands.
Rietjens IMCM; Division of Toxicology, Wageningen University and Research, P.O. Box 8000, Wageningen 6700 EA, The Netherlands.
Beekmann K; Wageningen Food Safety Research (WFSR), Part of Wageningen University and Research, P.O. Box 230, Wageningen 700 AE, The Netherlands.
Source(s):
Journal of agricultural and food chemistry [J Agric Food Chem] 2022 Sep 21; Vol. 70 (37), pp. 11759-11768. Date of Electronic Publication: 2022 Sep 07.
Language:
English
Abstract:
The advanced glycation endproduct carboxymethyllysine and its precursor fructoselysine are present in heated, processed food products and are considered potentially hazardous for human health. Upon dietary exposure, they can be degraded by human colonic gut microbiota, reducing internal exposure. Pronounced interindividual and intraindividual differences in these metabolic degradations were found in anaerobic incubations with human fecal slurries in vitro. The average capacity to degrade fructoselysine was 27.7-fold higher than that for carboxymethyllysine, and degradation capacities for these two compounds were not correlated ( R ² = 0.08). Analysis of the bacterial composition revealed that interindividual differences outweighed intraindividual differences, and multiple genera were correlated with the individuals' carboxymethyllysine and fructoselysine degradation capacities (e.g., Akkermansia , Alistipes ).

Additional Information

Journal Info:

Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

Imprint Name(s):

Original Publication: Washington, American Chemical Society.

MeSH Terms:

Gastrointestinal Microbiome*
Feces/microbiology ; Glycation End Products, Advanced/metabolism ; Humans ; Lysine/analogs & derivatives ; Lysine/metabolism ; RNA, Ribosomal, 16S

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Contributed Indexing:

Keywords: 16S rRNA analysis; advanced glycation end product; human gut microbiota; interindividual differences; intraindividual differences; new approach methodologies; temporal variability

Substance Nomenclature:

0 (Glycation End Products, Advanced)
0 (RNA, Ribosomal, 16S)
21291-40-7 (fructosyl-lysine)
70YDX3Z2O7 (N(6)-carboxymethyllysine)
K3Z4F929H6 (Lysine)

Entry Date(s):

Date Created: 20220907 Date Completed: 20220923 Latest Revision: 20220928

Update Code:

20221216

PubMed Central ID:

PMC9501902

DOI:

10.1021/acs.jafc.2c05756

PMID:

36069406

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Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine.

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