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Mesenchymal stem cells derived secretome as an innovative cell-free therapeutic approach.

  • Academic Journal
  • ABU-EL-RUB, EJLAL1,2 ejlal.abuelrub@yu.edu.jo
    KHASAWNEH, RAMADA R.1
    ALMAHASNEH, FATIMAH A.1
    ZEGALLAI, HANA M.3,4
  • Biocell. 2022, Vol. 46 Issue 3, p907-911. 5p.
  • Article
  • MESENCHYMAL stem cells
    CELLULAR therapy
    PARACRINE mechanisms
    CYTOKINES
    DEGENERATION (Pathology)
  • The paracrine and immunomodulatory cytokines secreted by mesenchymal stem cells (MSCs), generally referred to as the MSCs derived secretome, has substantial potential for the treatment of many chronic and degenerative diseases. MSCs secretome contains both common and disease specific cytokines and modulators that can be beneficial against a wide range of chronic diseases. Herein, we discuss the MSCs secretome composition profile and its translational applicability and the challenges surrounding its use in clinical settings. [ABSTRACT FROM AUTHOR]
Additional Information
Cytokines
Growth factors
Immuno-modulation
Mesencyhmal stem cells
Secretome
Copyright of Biocell is the property of Tech Science Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
1Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, 21163, Jordan
2Physiology and Pathophysiology, Faculty of Medicine, University of Manitoba, Winnipeg, R3E0W2, Canada
3Department of Pharmacology & Therapeutics, University of Manitoba, Winnipeg, R3E0W2, Canada
4DREAM, Children's Hospital Research Institute of Manitoba, Winnipeg, R3E0W2, Canada
0327-9545
10.32604/biocell.2022.018306
154703812
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