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Mesenchymal stem cells derived secretome as an innovative cell-free therapeutic approach.

  • Academic Journal
  • Biocell. 2022, Vol. 46 Issue 3, p907-911. 5p.
  • Article
  • The paracrine and immunomodulatory cytokines secreted by mesenchymal stem cells (MSCs), generally referred to as the MSCs derived secretome, has substantial potential for the treatment of many chronic and degenerative diseases. MSCs secretome contains both common and disease specific cytokines and modulators that can be beneficial against a wide range of chronic diseases. Herein, we discuss the MSCs secretome composition profile and its translational applicability and the challenges surrounding its use in clinical settings. [ABSTRACT FROM AUTHOR]
Additional Information
Growth factors
Mesencyhmal stem cells
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1Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, 21163, Jordan
2Physiology and Pathophysiology, Faculty of Medicine, University of Manitoba, Winnipeg, R3E0W2, Canada
3Department of Pharmacology & Therapeutics, University of Manitoba, Winnipeg, R3E0W2, Canada
4DREAM, Children's Hospital Research Institute of Manitoba, Winnipeg, R3E0W2, Canada