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Academic Journal
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Eye (London, England) [Eye (Lond)] 2011 May; Vol. 25 (5), pp. 578-86. Date of Electronic Publication: 2011 Apr 08.
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English
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Reduction of intraocular pressure (IOP) by pharmaceutical or surgical means has long been the standard treatment for glaucoma. A number of excellent drugs are available that are effective in reducing IOP. These drugs are typically applied as eye drops. However, patient adherence can be poor, thus reducing the clinical efficacy of the drugs. Several novel delivery systems designed to address the issue of adherence and to ensure consistent reduction of IOP are currently under development. These delivery systems include contact lenses-releasing glaucoma medications, injectables such as biodegradable micro- and nanoparticles, and surgically implanted systems. These new technologies are aimed at increasing clinical efficacy by offering multiple delivery options and are capable of managing IOP for several months. There is also a desire to have complementary neuroprotective approaches for those who continue to show progression, despite IOP reduction. Many potential neuroprotective agents are not suitable for traditional oral or drop formulations. Their potential is dependent on developing suitable delivery systems that can provide the drugs in a sustained, local manner to the retina and optic nerve. Drug delivery systems have the potential to improve patient adherence, reduce side effects, increase efficacy, and ultimately, preserve sight for glaucoma patients. In this review, we discuss benefits and limitations of the current systems of delivery and application, as well as those on the horizon.
Additional Information
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8703986 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5454 (Electronic) Linking ISSN: 0950222X NLM ISO Abbreviation: Eye (Lond) Subsets: MEDLINE
Publication: : London : Nature Publishing Group
Original Publication: [London : Ophthalmological Society of the United Kingdom, 1987-
Original Publication: [London : Ophthalmological Society of the United Kingdom, 1987-
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Clin Ther. 2000 Feb;22(2):167-208. (PMID: 10743979)
Eur J Pharm Sci. 2003 Sep;20(1):73-81. (PMID: 13678795)
Am J Public Health. 1993 May;83(5):711-6. (PMID: 8484454)
Eye (Lond). 1998;12 ( Pt 2):234-6. (PMID: 9683946)
Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2702-7. (PMID: 12766076)
Vision Res. 1998 May;38(10):1505-15. (PMID: 9667015)
South Med J. 1976 Oct;69(10):1296-8. (PMID: 982104)
Neurology. 1996 May;46(5):1244-9. (PMID: 8628460)
Tissue Eng. 2004 Nov-Dec;10(11-12):1617-22. (PMID: 15684670)
Clin Exp Optom. 2009 Jul;92(4):343-8. (PMID: 19389129)
Adv Drug Deliv Rev. 1997 Oct 13;28(1):5-24. (PMID: 10837562)
J Control Release. 2002 Oct 4;83(2):223-30. (PMID: 12363448)
Curr Eye Res. 2010 Mar;35(3):192-201. (PMID: 20373877)
Eur J Pharmacol. 2005 Mar 28;511(2-3):191-8. (PMID: 15792788)
Curr Opin Ophthalmol. 2011 Mar;22(2):78-86. (PMID: 21252670)
J Ocul Pharmacol Ther. 2004 Feb;20(1):43-53. (PMID: 15006158)
Ophthalmology. 2002 Jun;109(6):1047-51. (PMID: 12045042)
Invest Ophthalmol Vis Sci. 2002 Jun;43(6):1809-16. (PMID: 12036983)
Trans Am Ophthalmol Soc. 2009 Dec;107:60-70. (PMID: 20126483)
Exp Eye Res. 2009 Oct;89(4):538-48. (PMID: 19524566)
Nature. 1992 Aug 6;358(6386):502-4. (PMID: 1641039)
Clin Ther. 2001 Mar;23(3):440-50. (PMID: 11318078)
Expert Opin Drug Deliv. 2010 Jun;7(6):765-80. (PMID: 20408742)
Exp Cell Res. 1988 Sep;178(1):1-17. (PMID: 2842173)
Adv Drug Deliv Rev. 2006 Nov 15;58(11):1131-5. (PMID: 17097758)
Acta Ophthalmol Scand. 1997 Oct;75(5):589-91. (PMID: 9469562)
Pharm Res. 1994 Sep;11(9):1278-82. (PMID: 7816756)
Exp Eye Res. 2009 Dec;89(6):1012-20. (PMID: 19735654)
Pharm Res. 2009 Apr;26(4):770-84. (PMID: 19184374)
Ophthalmology. 2001 Jun;108(6):1015-22. (PMID: 11382622)
Br J Ophthalmol. 1996 May;80(5):389-93. (PMID: 8695555)
Curr Pharm Biotechnol. 2011 Mar 1;12(3):347-51. (PMID: 20939799)
Ophthalmology. 2001 May;108(5):882-6. (PMID: 11320017)
Exp Eye Res. 2010 Nov;91(5):554-66. (PMID: 20800593)
J Nanosci Nanotechnol. 2006 Aug;6(8):2403-7. (PMID: 17037847)
Eur J Pharm Biopharm. 2000 Jul;50(1):27-46. (PMID: 10840191)
Surv Ophthalmol. 2008 Nov;53 Suppl1:S57-68. (PMID: 19038625)
Ophthalmology. 1979 Jan;86(1):43-50. (PMID: 530564)
Curr Opin Ophthalmol. 2004 Apr;15(2):102-6. (PMID: 15021220)
Optom Vis Sci. 2011 Jan;88(1):36-8. (PMID: 21131876)
Br J Ophthalmol. 1998 Jun;82(6):630-3. (PMID: 9797662)
Am J Ophthalmol. 2000 Oct;130(4):429-40. (PMID: 11024415)
Arch Ophthalmol. 1977 Apr;95(4):601-4. (PMID: 322648)
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3978-83. (PMID: 9520478)
Br J Ophthalmol. 2005 Nov;89(11):1420-2. (PMID: 16234444)
Ophthalmology. 2007 Nov;114(11):1965-72. (PMID: 17628686)
Int J Pharm. 2000 Mar 30;198(1):29-38. (PMID: 10722948)
Arch Ophthalmol. 2003 Jan;121(1):48-56. (PMID: 12523884)
Science. 1990 Sep 28;249(4976):1527-33. (PMID: 2218494)
Drugs. 2000 Mar;59(3):411-34. (PMID: 10776828)
Am J Ophthalmol. 2009 Aug;148(2):186-191.e2. (PMID: 19464671)
J Pharm Sci. 2007 Mar;96(3):558-68. (PMID: 17177208)
Trends Pharmacol Sci. 2010 Dec;31(12):596-604. (PMID: 21035878)
Ophthalmology. 2010 Jun;117(6):1134-1146.e3. (PMID: 20417567)
Graefes Arch Clin Exp Ophthalmol. 2010 Aug;248(8):1105-16. (PMID: 20229104)
Graefes Arch Clin Exp Ophthalmol. 2006 Nov;244(11):1491-6. (PMID: 16628416)
Arch Ophthalmol. 2004 Apr;122(4):532-8. (PMID: 15078671)
Drugs Aging. 2005;22(1):1-21. (PMID: 15663346)
Ann Ophthalmol. 1978 Mar;10(3):325-30. (PMID: 655539)
Gene Ther. 2010 Feb;17(2):181-9. (PMID: 19741732)
Curr Mol Med. 2010 Dec;10(9):824-40. (PMID: 21091423)
J Glaucoma. 2008 Mar;17(2):147-56. (PMID: 18344762)
J Pharm Sci. 2003 Aug;92(8):1582-91. (PMID: 12884245)
Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3896-901. (PMID: 16505355)
Am J Ophthalmol. 1998 Oct;126(4):498-505. (PMID: 9780094)
PLoS One. 2006 Dec 20;1:e38. (PMID: 17183666)
Arch Ophthalmol. 2010 Jan;128(1):81-7. (PMID: 20065222)
Arch Ophthalmol. 2009 Aug;127(8):1043-7. (PMID: 19667343)
Curr Med Chem. 2008;15(14):1407-11. (PMID: 18537618)
J Microencapsul. 2009 Feb;26(1):18-26. (PMID: 18465288)
Arch Ophthalmol. 1975 Aug;93(8):587-90. (PMID: 1164218)
Pharm Res. 2006 May;23(5):847-63. (PMID: 16715375)
Acta Ophthalmol Scand. 2005 Dec;83(6):723-8. (PMID: 16396651)
Arch Ophthalmol. 2010 Sep;128(9):1146-50. (PMID: 20837798)
Arch Ophthalmol. 2009 Jul;127(7):900-5. (PMID: 19597112)
Exp Eye Res. 2008 Jan;86(1):92-104. (PMID: 17983616)
J Microencapsul. 2006 Aug;23(5):471-9. (PMID: 16980270)
Expert Opin Investig Drugs. 2001 Apr;10(4):679-94. (PMID: 11281818)
Ophthalmology. 2006 Mar;113(3):431-6. (PMID: 16458967)
Clin Ther. 2000 Feb;22(2):167-208. (PMID: 10743979)
Eur J Pharm Sci. 2003 Sep;20(1):73-81. (PMID: 13678795)
Am J Public Health. 1993 May;83(5):711-6. (PMID: 8484454)
Eye (Lond). 1998;12 ( Pt 2):234-6. (PMID: 9683946)
Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2702-7. (PMID: 12766076)
Vision Res. 1998 May;38(10):1505-15. (PMID: 9667015)
South Med J. 1976 Oct;69(10):1296-8. (PMID: 982104)
Neurology. 1996 May;46(5):1244-9. (PMID: 8628460)
Tissue Eng. 2004 Nov-Dec;10(11-12):1617-22. (PMID: 15684670)
Clin Exp Optom. 2009 Jul;92(4):343-8. (PMID: 19389129)
Adv Drug Deliv Rev. 1997 Oct 13;28(1):5-24. (PMID: 10837562)
J Control Release. 2002 Oct 4;83(2):223-30. (PMID: 12363448)
Curr Eye Res. 2010 Mar;35(3):192-201. (PMID: 20373877)
Eur J Pharmacol. 2005 Mar 28;511(2-3):191-8. (PMID: 15792788)
Curr Opin Ophthalmol. 2011 Mar;22(2):78-86. (PMID: 21252670)
DP2 OD007338 United States OD NIH HHS; DP2OD007338 United States OD NIH HHS; EY017142 United States EY NEI NIH HHS
0 (Neuroprotective Agents)
0 (Ophthalmic Solutions)
0 (Ophthalmic Solutions)
Date Created: 20110409 Date Completed: 20110824 Latest Revision: 20220310
20221216
PMC3171267
10.1038/eye.2011.82
21475311