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On the role of anisotropy of membrane constituents in formation of a membrane neck during budding of a multicomponent membrane.

  • Academic Journal
  • Iglic A; Laboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia.
    Babnik B
    Bohinc K
    Fosnaric M
    Hägerstrand H
    Kralj-Iglic V
  • Journal of biomechanics [J Biomech] 2007; Vol. 40 (3), pp. 579-85. Date of Electronic Publication: 2006 Apr 03.
  • English
  • The expression for the isotropic membrane bending energy was generalized for the case of a multicomponent membrane where the membrane constituents (single molecules or small complexes of molecules-membrane inclusions) were assumed to be anisotropic. Using this generalized expression for the membrane energy it was shown that the change of intrinsic shape of membrane components may induce first-order-like shape transitions leading to the formation of a membrane neck. The predicted discontinuous membrane shape transition and the concomitant lateral segregation of membrane components were applied to study membrane budding. Based on the results presented we conclude that the budding process might be driven by accumulation of anisotropic membrane components in the necks connecting the bud and the parent membrane, and by accumulation of isotropic (conical) membrane components on the bud. Both processes may strongly depend on the intrinsic shape of membrane components and on the direct interactions between them.
Additional Information
Publisher: Elsevier Science Country of Publication: United States NLM ID: 0157375 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0021-9290 (Print) Linking ISSN: 00219290 NLM ISO Abbreviation: J Biomech Subsets: MEDLINE
Original Publication: New York ; Oxford : Elsevier Science
Date Created: 20060406 Date Completed: 20070320 Latest Revision: 20131121