scroll to top

Loading icon

0

Mobile Menu

Header Layout

Page title

Review of tumoral calcinosis: A rare clinico-pathological entity.

  • Academic Journal
  • Fathi I; Ibrahim Fathi, Mahmoud Sakr, Department of Surgery, Faculty of Medicine, University of Alexandria, Raml Station, Alexandria 21500, Egypt.
    Sakr M; Ibrahim Fathi, Mahmoud Sakr, Department of Surgery, Faculty of Medicine, University of Alexandria, Raml Station, Alexandria 21500, Egypt.
  • World journal of clinical cases [World J Clin Cases] 2014 Sep 16; Vol. 2 (9), pp. 409-14.
  • English
  • Tumoral calcinosis (TC) has long been a controversial clinico-pathological entity. Its pathogenesis and genetic background have been gradually unravelled since its first description in 1943. According to the presence or absence of an underlying calcifying disease process, TC has been divided into primary and secondary varieties. Two subtypes of the primary variety exist; a hyper-phosphatemic type with familial basis represented by mutations in GalNAc transferase 3 gene (GALNT3), KLOTHO or Fibroblast growth factor 23 (FGF23) genes, and a normo-phosphatemic type with growing evidence of underlying familial base represented by mutation in SAMD9 gene. The secondary variety is mainly associated with chronic renal failure and the resulting secondary or tertiary hyperparathyroidism. Diagnosis of TC relies on typical radiographic features (on plain radiographs and computed tomography) and the biochemical profile. Magnetic resonance imaging can be done in difficult cases, and scintigraphy reflects the disease activity. Treatment is mainly surgical for the primary variety; however, a stage-oriented conservative approach using phosphate binders, phosphate restricted diets and acetazolamide should be considered before the surgical approach is pursued due to the high rate of recurrences and complications after surgical intervention. Medical treatment is the mainstay for treatment of the secondary variety, with failure warranting subtotal or total parathyroidectomy. Surgical intervention in these patients should be kept as a last resort.
Additional Information
Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 101618806 Publication Model: Print Cited Medium: Print ISSN: 2307-8960 (Print) Linking ISSN: 23078960 NLM ISO Abbreviation: World J Clin Cases Subsets: PubMed not MEDLINE
Publication: 2014-: Pleasanton, CA : Baishideng Publishing Group
Original Publication: Hong Kong, China : Baishideng Publishing Group Co., Limited, [2013]-
J Bone Miner Res. 2000 Oct;15(10):2056-7. (PMID: 11028461)
Spine (Phila Pa 1976). 1996 Jan 15;21(2):249-52. (PMID: 8720412)
J Int Med Res. 1992 Sep;20(5):435-43. (PMID: 1451924)
Nat Genet. 2004 Jun;36(6):579-81. (PMID: 15133511)
Am J Surg Pathol. 1993 Aug;17(8):788-802. (PMID: 8338191)
Orthopedics. 2004 Oct;27(10):1104-7. (PMID: 15553954)
Histopathology. 1997 Jul;31(1):18-24. (PMID: 9253620)
Clin Imaging. 2003 May-Jun;27(3):184-6. (PMID: 12727056)
Clin Imaging. 1992 Jan-Mar;16(1):49-51. (PMID: 1540864)
J Musculoskelet Neuronal Interact. 2007 Oct-Dec;7(4):318-9. (PMID: 18094491)
Nephrol Dial Transplant. 1996;11 Suppl 3:37-42. (PMID: 8840310)
J Bone Joint Surg Am. 1967 Jun;49(4):721-31. (PMID: 6026005)
Rheumatol Int. 2005 Jan;25(1):55-9. (PMID: 13680142)
Radiographics. 2006 May-Jun;26(3):871-85. (PMID: 16702460)
Clin Imaging. 2006 Jan-Feb;30(1):66-8. (PMID: 16377490)
Eur J Dermatol. 2000 Jan-Feb;10(1):52-4. (PMID: 10694300)
Br Med J. 1973 Jan 20;1(5846):147-9. (PMID: 4145235)
Br J Radiol. 1966 Jul;39(463):526-32. (PMID: 5942000)
Arch Surg. 1993 Jul;128(7):737-44; discussion 744-5. (PMID: 8317954)
Q J Med. 1987 Jun;63(242):493-503. (PMID: 3659264)
Am J Nephrol. 1997;17(1):93-5. (PMID: 9057960)
Ann Intern Med. 1982 May;96(5):586-91. (PMID: 6896123)
Am J Med. 1965 Jan;38:105-18. (PMID: 14251895)
Ann Dermatol Venereol. 1977 Feb;104(2):136-40. (PMID: 869449)
Skeletal Radiol. 1995 Nov;24(8):573-8. (PMID: 8614855)
Int J Surg Pathol. 2012 Oct;20(5):462-73. (PMID: 22614164)
J Invest Dermatol. 2011 Mar;131(3):662-9. (PMID: 21160498)
Saudi J Kidney Dis Transpl. 2008 Jan;19(1):105-6. (PMID: 18087136)
Kidney Int. 2009 Nov;76(10):1027-34. (PMID: 19675530)
Aesthetic Plast Surg. 2012 Oct;36(5):1194-7. (PMID: 22653143)
J Clin Endocrinol Metab. 1980 Apr;50(4):648-53. (PMID: 7364922)
J Rheumatol. 2006 Jan;33(1):119-26. (PMID: 16395759)
J Bone Joint Surg Am. 1949 Jan;31A(1):132-40. (PMID: 18122879)
Skeletal Radiol. 1996 May;25(4):388-90. (PMID: 8738007)
Br Med J. 1969 Jan 18;1(5637):153-5. (PMID: 5762276)
J Hand Surg Am. 1994 Sep;19(5):809-12. (PMID: 7806807)
Am J Orthop (Belle Mead NJ). 2011 May;40(5):247-52. (PMID: 21734933)
J Bone Joint Surg Am. 1989 Sep;71(8):1244-9. (PMID: 2777854)
Nephrol Dial Transplant. 2000 Oct;15(10):1691-3. (PMID: 11007844)
Skeletal Radiol. 1995 Feb;24(2):148-51. (PMID: 7747184)
Orthop Rev. 1989 Jun;18(6):687-90. (PMID: 2664669)
Radiol Case Rep. 2015 Nov 06;4(4):336. (PMID: 27307838)
Ann Intern Med. 1972 Nov;77(5):741-5. (PMID: 4538804)
Int J Dermatol. 1996 Apr;35(4):265-71. (PMID: 8786184)
J Clin Endocrinol Metab. 2005 Apr;90(4):2424-7. (PMID: 15687325)
Bone. 1995 Apr;16(4 Suppl):247S-250S. (PMID: 7626311)
S Afr Med J. 1978 Dec 2;54(23):963-6. (PMID: 746428)
J Bone Joint Surg Am. 1981 Sep;63(7):1167-9. (PMID: 6268638)
Hum Mol Genet. 2005 Feb 1;14(3):385-90. (PMID: 15590700)
Radiology. 1990 Jan;174(1):215-22. (PMID: 2294551)
Int J Oral Maxillofac Surg. 1991 Feb;20(1):36-7. (PMID: 2019781)
Oral Surg Oral Med Oral Pathol. 1994 Feb;77(2):158-66. (PMID: 8139834)
Eur J Intern Med. 2006 Oct;17(6):436-8. (PMID: 16962954)
Am J Orthop (Belle Mead NJ). 2011 Sep;40(9):E170-6. (PMID: 22022679)
Br J Radiol. 1974 Oct;47(562):734-6. (PMID: 4433987)
Zentralbl Allg Pathol. 1951 Jan 2;87(1):1-15. (PMID: 14828927)
Spine (Phila Pa 1976). 2001 Aug 1;26(15):1673-9. (PMID: 11474354)
Keywords: Calcification; FGF23; GALNT3; KLOTHO; Phosphate binders; Primary; Secondary; Surgical excision; Tumoral calcinosis
Date Created: 20140919 Date Completed: 20140918 Latest Revision: 20211021
20220301
PMC4163761
10.12998/wjcc.v2.i9.409
25232542