Samaşca G; Department of Immunology; 'Iuliu Haţieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania. firstname.lastname@example.org
Roumanian archives of microbiology and immunology [Roum Arch Microbiol Immunol] 2011 Oct-Dec; Vol. 70 (4), pp. 178-85.
Last consensus in celiac disease in 2008 conducted under the aegis of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition jointly with North American Society of Pediatric Gastroenterology, Hepatology and Nutrition reveals the following: "celiac disease is a chronic immune-mediated enteropathy characterized by sensitization to gluten. That can affect any organ or system, with a wide range of clinical manifestations of variable severity". Thus, in recent years, clinical picture of celiac disease has changed the old paradigm--bowel disease with villous atrophy and malnutrition, being replaced with the new paradigm--multi-organ autoimmune disease, affecting many organs and systems throughout but with more less specific symptoms, which undiagnosed leads to delayed diagnosis, at a late-onset disease and long-term major complications as the risk of cancer. According to this consensus "the serological diagnosis of celiac disease is based on high sensitivity and specificity tests", but in line with changing clinical features of celiac disease, its diagnosis has undergone significant changes in recent years. These changes in the diagnosis of celiac disease, we have decided to analyze them.
Publisher: Institutul Cantacuzino Country of Publication: Romania NLM ID: 9204717 Publication Model: Print Cited Medium: Print ISSN: 1222-3891 (Print) Linking ISSN: 12223891 NLM ISO Abbreviation: Roum Arch Microbiol Immunol Subsets: MEDLINE
Original Publication: Bucuresti, Româna : Institutul Cantacuzino, [1991-
Date Created: 20120510 Date Completed: 20120524 Latest Revision: 20120509