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Boosting in the age of Omicron.
Publication Type: Academic Journal
Source(s): eLife. 4/17/2023, p1-2. 2p.
Evaluation of antibody kinetics and durability in healthy individuals vaccinated with inactivated COVID- 19 vaccine (CoronaVac): A cross- sectional and cohort study in Zhejiang, China.
Publication Type: Academic Journal
Source(s): eLife. 4/17/2023, p1-16. 16p.
Abstract: Background: Although inactivated COVID- 19 vaccines are proven to be safe and effective in the general population, the dynamic response and duration of antibodies after vaccination in the real world should be further assessed. Methods: We enrolled 1067...
Projected resurgence of COVID-19 in the United States in July--December 2021 resulting from the increased transmissibility of the Delta variant and faltering vaccination.
Publication Type: Academic Journal
Source(s): eLife. 6/24/2022, p1-17. 17p.
Abstract: In Spring 2021, the highly transmissible SARS- CoV- 2 Delta variant began to cause increases in cases, hospitalizations, and deaths in parts of the United States. At the time, with slowed vaccination uptake, this novel variant was expected to increase ...
COVID-19 pandemic dynamics in South Africa and epidemiological characteristics of three variants of concern (Beta, Delta, and Omicron).
Publication Type: Academic Journal
Source(s): eLife. 8/9/2022, p1-50. 50p.
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) have been key drivers of new coronavirus disease 2019 (COVID-19) pandemic waves. To better understand variant epidemiologic characteristics, here we apply a model-i...
Exploratory data on the clinical efficacy of monoclonal antibodies against SARS-CoV-2 Omicron variant of concern.
Publication Type: Academic Journal
Source(s): eLife. 11/22/2022, p1-17. 17p.
Abstract: Background: Recent in-vitro data have shown that the activity of monoclonal antibodies (mAbs) targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) varies according to the variant of concern (VOC). No studies have compared the clinical...
Projected resurgence of COVID-19 in the United States in July—December 2021 resulting from the increased transmissibility of the Delta variant and faltering vaccination
Publication Type: Academic Journal
Source(s): eLife, Vol 11 (2022)
Abstract: In Spring 2021, the highly transmissible SARS-CoV-2 Delta variant began to cause increases in cases, hospitalizations, and deaths in parts of the United States. At the time, with slowed vaccination uptake, this novel variant was expected to increase th...
A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variants.
Publication Type: Academic Journal
Source(s): eLife. 9/16/2022, p1-23. 23p.
Abstract: Large-scale populations in the world have been vaccinated with COVID-19 vaccines, however, breakthrough infections of SARS-CoV-2 are still growing rapidly due to the emergence of immune-evasive variants, especially Omicron. It is urgent to develop effe...
The unmitigated profile of COVID-19 infectiousness.
Publication Type: Academic Journal
Source(s): eLife. 8/19/2022, p1-37. 37p.
Abstract: Quantifying the temporal dynamics of infectiousness of individuals infected with SARS-CoV-2 is crucial for understanding the spread of COVID-19 and for evaluating the effectiveness of mitigation strategies. Many studies have estimated the infectiousnes...
Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics.
Publication Type: Academic Journal
Source(s): eLife. 3/28/2023, p1-21. 21p.
Abstract: SARS-CoV-2 emergent variants are characterized by increased viral fitness and each shows multiple mutations predominantly localized to the spike (S) protein. Here, amide hydrogen/deuterium exchange mass spectrometry has been applied to track changes in...
The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA.1 evolution.
Publication Type: Academic Journal
Source(s): eLife. 2/23/2023, p1-19. 19p.
Abstract: The Omicron BA.1 variant of SARS-CoV-2 escapes convalescent sera and monoclonal antibodies that are effective against earlier strains of the virus. This immune evasion is largely a consequence of mutations in the BA.1 receptor binding domain (RBD), the...