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KDM5 Lysine Demethylases in Pathogenesis, from Basic Science Discovery to the Clinic.

Publication Type: Academic Journal

Source(s): Advances in experimental medicine and biology [Adv Exp Med Biol] 2023; Vol. 1433, pp. 113-137.

Authors:

Abstract: The histone lysine demethylase 5 (KDM5) family proteins are Fe 2+ and α-ketoglutarate-dependent dioxygenases, with jumonji C (JmjC) domain as their catalytic core and several plant homeodomains (PHDs) to bind different histone methylation marks. These ...

Genetic risk factors for autism-spectrum disorders: a systematic review based on systematic reviews and meta-analysis.

Publication Type: Academic Journal

Source(s): Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2021 Jun; Vol. 128 (6), pp. 717-734. Date of Electronic Publication: 2021 Jun 11.

Authors:

Abstract: Background: Based on recent evidence, more than 200 susceptibility genes have been identified to be associated with autism until now. Correspondingly, cytogenetic abnormalities have been reported for almost every chromosome. While the results of multip...

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