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Synthesis of Tritium Labelled and Photoactivatable N-Acyl- L-homoserine Lactones: Inter-Kingdom Signalling Molecules.

Publication Type: Academic Journal

Source(s): European Journal of Organic Chemistry. Jan2014, Vol. 2014 Issue 3, p592-597. 6p.

Abstract: N-Acyl- L-homoserine lactones (AHLs) are signal molecules that are synthesized in nature by Gram-negative bacteria. They allow communication between bacteria (quorum sensing) and between microorganisms and their eukaryotic host cells (inter-kingdom sig...

Deuterium-labelled N-acyl- l-homoserine lactones (AHLs)-inter-kingdom signalling molecules-synthesis, structural studies, and interactions with model lipid membranes.

Publication Type: Academic Journal

Source(s): Analytical & Bioanalytical Chemistry. Jul2012, Vol. 403 Issue 2, p473-482. 10p.

Abstract: N-Acyl- l-homoserine lactones (AHLs) are synthesized by Gram-negative bacteria. These quorum-sensing molecules play an important role in the context of bacterial infection and biofilm formation. They also allow communication between microorganisms and ...

5-(Hydroxyphenyl)-γ-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan-3-ols, Is Able to Reach the Brain: Evidence from Different in Silico , In Vitro and In Vivo Experimental Models.

Publication Type: Academic Journal

Source(s): Nutrients [Nutrients] 2019 Nov 05; Vol. 11 (11). Date of Electronic Publication: 2019 Nov 05.

Abstract: Phenolic compounds have been recognized as promising compounds for the prevention of chronic diseases, including neurodegenerative ones. However, phenolics like flavan-3-ols (F3O) are poorly absorbed along the gastrointestinal tract and structurally re...

Cellular Effects of Bacterial N-3-Oxo-Dodecanoyl-L-Homoserine Lactone on the Sponge Suberites domuncula (Olivi, 1792): Insights into an Intimate Inter-Kingdom Dialogue.

Publication Type: Academic Journal

Source(s): PLoS ONE. May2014, Vol. 9 Issue 5, p1-10. 10p.

Abstract: Sponges and bacteria have lived together in complex consortia for 700 million years. As filter feeders, sponges prey on bacteria. Nevertheless, some bacteria are associated with sponges in symbiotic relationships. To enable this association, sponges an...

Access to original spirocyclic derivatives via inter- or intramolecular reaction mediated by manganese(III) acetate

Publication Type: Academic Journal

Source(s): Tetrahedron. May2012, Vol. 68 Issue 18, p3596-3604. 9p.

Abstract: Abstract: An easily reproducible protocol allowing inter- or intramolecular spirocyclization on β-dicarbonyl structures is described. This methodology could afford a wide variety of spirocyclic pharmacophores. As examples, highly substituted spirobenzo...

Clinical pharmacokinetics of the new oral camptothecin gimatecan: The inter-patient variability is related to α1-acid glycoprotein plasma levels

Publication Type: Academic Journal

Source(s): European Journal of Cancer. Feb2010, Vol. 46 Issue 3, p505-516. 12p.

Abstract: Abstract: Aim of the study: To determine the pharmacokinetics of gimatecan, a camptothecin with a lipophilic substitution in position 7, given orally to patients participating in the phase I study. Methods: Pharmacokinetics was evaluated in 78 patients...

Effects of γ-Valerolactone/H 2 O Solvent on the Degradation of pubescens for Its Fullest Utilization.

Publication Type: Academic Journal

Source(s): Journal of agricultural and food chemistry [J Agric Food Chem] 2018 Jun 20; Vol. 66 (24), pp. 6094-6103. Date of Electronic Publication: 2018 Jun 06.


Abstract: Solvent-thermal conversion of biomass was promising for obtaining value-added chemicals. However, little was known about the interactions between solvents and biomass in the process, which hindered the effective utilization of biomass. The effects of γ...

Indole is an inter-species biofilm signal mediated by SdiA.

Publication Type: Academic Journal

Source(s): BMC Microbiology. 2007, Vol. 7, p42-15. 15p.

Abstract: Background: As a stationary phase signal, indole is secreted in large quantities into rich medium by Escherichia coli and has been shown to control several genes (e.g., astD, tnaB, gabT), multi-drug exporters, and the pathogenicity island of E. coli; h...

Chemical modulation of microtubule structure through the laulimalide/peloruside site.

Publication Type: Academic Journal

Source(s): Structure (London, England : 1993) [Structure] 2023 Jan 05; Vol. 31 (1), pp. 88-99.e5. Date of Electronic Publication: 2022 Dec 02.

Abstract: Taxanes are microtubule-stabilizing agents used in the treatment of many solid tumors, but they often involve side effects affecting the peripheral nervous system. It has been proposed that this could be related to structural modifications on the filam...

Cistobislactone, an undescribed variant of 14-membered bislactonic macrodiolide, from old-lady octopus Cistopus indicus (family Octopodidae) attenuates inflammatory lipoxygenase.

Publication Type: Academic Journal

Source(s): Natural product research [Nat Prod Res] 2022 Jun; Vol. 36 (12), pp. 3002-3012. Date of Electronic Publication: 2021 Jun 14.

Abstract: Chemical evaluation of specialised metabolites from the old-lady marine octopus Cistopus indicus (family Octopodidae) led to the isolation of an undescribed 14-membered bislactonic macrodiolide cistobislactone, which was characterized as 12-(4'-ethyl-6...