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Advanced Search Results For "Abdelmohsen, Kotb"

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 "Abdelmohsen, Kotb"
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A BDNF-TrkB autocrine loop enhances senescent cell viability

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Abstract: Selective elimination of senescent cells is an approach that has shown promise to ameliorate age-associated pathologies in preclinical models. Here the authors report that BDNF enhances senescent cell viability via TrkB in cultured cells, and that TrkB...

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Systematic identification of NF90 target RNAs by iCLIP analysis

Publication Type: Academic Journal

Source(s): Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)

Abstract: Abstract RNA-binding proteins (RBPs) interact with and determine the fate of many cellular RNAs directing numerous essential roles in cellular physiology. Nuclear Factor 90 (NF90) is an RBP encoded by the interleukin enhancer-binding factor 3 (ILF3) ge...

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Identification of gingerenone A as a novel senolytic compound.

Publication Type: Academic Journal

Source(s): PLoS ONE, Vol 17, Iss 3, p e0266135 (2022)

Abstract: Senescent cells accumulate with aging and have been shown to contribute to age-associated diseases and organ dysfunction. Eliminating senescent cells with senolytic drugs has been shown to improve age phenotypes in mouse models and there is some initia...

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NQO1 protects obese mice through improvements in glucose and lipid metabolism

Publication Type: Academic Journal

Source(s): npj Aging and Mechanisms of Disease, Vol 6, Iss 1, Pp 1-18 (2020)

Abstract: Abstract Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis ...

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A BDNF-TrkB autocrine loop enhances senescent cell viability.

Publication Type: Academic Journal

Source(s): Nature Communications; 10/20/2022, Vol. 13 Issue 1, p1-17, 17p

Abstract: Copyright of Nature Communications is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, ...

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Reduced endosomal microautophagy activity in aging associates with enhanced exocyst‐mediated protein secretion.

Publication Type: Academic Journal

Source(s): Aging Cell; Oct2022, Vol. 21 Issue 10, p1-24, 24p

Abstract: Copyright of Aging Cell is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email ar...

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Mitochondrial RNA in Alzheimer’s Disease Circulating Extracellular Vesicles

Publication Type: Academic Journal

Source(s): Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Abstract: Alzheimer’s disease (AD) is the most common type of dementia. Amyloid β (Aβ) plaques, tau-containing neurofibrillary tangles, and neuronal loss leading to brain atrophy are pathologic hallmarks of AD. Given the importance of early diagnosis, extensive ...

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Evolutionarily Selected Overexpression of the Cytokine BAFF Enhances Mucosal Immune Response Against P. falciparum

Publication Type: Academic Journal

Source(s): Frontiers in Immunology, Vol 11 (2020)

Abstract: We have previously shown that a variant of the TNFSF13B gene that we called BAFF-var increases the production of the cytokine BAFF, upregulating humoral immunity and increasing the risk for certain autoimmune diseases. In addition, genetic population s...

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The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets

Publication Type: Academic Journal

Source(s): Cells, Vol 10, Iss 1740, p 1740 (2021)

Abstract: Senescence is linked to a wide range of age-associated diseases and physiological declines. Thus, senotherapeutics are emerging to suppress the detrimental effects of senescence either by senomorphics or senolytics. Senomorphics suppress the traits ass...

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