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Advanced Search Results For "Acosta, K. Alexandra"

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 "Acosta, K. Alexandra"
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Routine use of low-dose glucarpidase following high-dose methotrexate in adult patients with CNS lymphoma: an open-label, multi-center phase I study

Publication Type: Academic Journal

Source(s): BMC Cancer, Vol 22, Iss 1, Pp 1-10 (2022)

Abstract: Abstract Background High-dose methotrexate (HD-MTX) has broad use in the treatment of central nervous system (CNS) malignancies but confers significant toxicity without inpatient hydration and monitoring. Glucarpidase is a bacterial recombinant enzyme ...

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PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Abstract: Bulky DNA adducts are important replication-blocking lesions. Here the authors reveal that homologous recombination at bulky adducts in mammalian cells involves post-replicative gap repair in a PrimPol dependent manner.

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Abstracts from the Food Allergy and Anaphylaxis Meeting 2016

Publication Type: Academic Journal

Source(s): Clinical and Translational Allergy, Vol 7, Iss S1, Pp 1-79 (2017)

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Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Publication Type: Periodical

Source(s): The Lancet; February 2022, Vol. 399 Issue: 10325 p665-676, 12p

Abstract: Casirivimab and imdevimab are non-competing monoclonal antibodies that bind to two different sites on the receptor binding domain of the SARS-CoV-2 spike glycoprotein, blocking viral entry into host cells. We aimed to evaluate the efficacy and safety o...

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Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Publication Type: Periodical

Source(s): The Lancet; January 2022, Vol. 399 Issue: 10320 p143-151, 9p

Abstract: Aspirin has been proposed as a treatment for COVID-19 on the basis of its anti-thrombotic properties. We aimed to evaluate the efficacy and safety of aspirin in patients admitted to hospital with COVID-19.

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Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Publication Type: Periodical

Source(s): The Lancet; May-June 2021, Vol. 397 Issue: 10289 p2049-2059, 11p

Abstract: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.

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Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Publication Type: Periodical

Source(s): The Lancet; May 2021, Vol. 397 Issue: 10285 p1637-1645, 9p

Abstract: In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.

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Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Publication Type: Periodical

Source(s): The Lancet; February 2021, Vol. 397 Issue: 10274 p605-612, 8p

Abstract: Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.

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Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Publication Type: Periodical

Source(s): The Lancet; November 2020, Vol. 396 Issue: 10262 p1574-1584, 11p

Abstract: Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imagi...

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