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Advanced Search Results For "Alter, Jonathan"

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 "Alter, Jonathan"
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The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemia

Publication Type: Academic Journal

Source(s): mBio, Vol 13, Iss 4 (2022)

Abstract: ABSTRACT Persistent SARS-CoV-2 replication and systemic dissemination are linked to increased COVID-19 disease severity and mortality. However, the precise immune profiles that track with enhanced viral clearance, particularly from systemic RNAemia, re...

Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

Abstract: Convalescent plasma (CP) has been trialed as a therapy for SARS-CoV-2 symptoms, but its heterogenous nature precludes uniform outcomes. Here the authors perform deep profiling of CP, as well as plasma of CP recipients before and after transfer, to find...


Sequence and vector shapes vaccine induced antibody effector functions in HIV vaccine trials.

Publication Type: Academic Journal

Source(s): PLoS Pathogens, Vol 17, Iss 11, p e1010016 (2021)

Abstract: Despite the advent of long-acting anti-retroviral therapy able to control and prevent infection, a preventative vaccine remains a global priority for the elimination of HIV. The moderately protective RV144 vaccine trial suggested functional IgG1 and Ig...

Liver Fibrosis Index FIB‐4 Is Associated With Mortality in COVID‐19

Publication Type: Academic Journal

Source(s): Hepatology Communications, Vol 5, Iss 3, Pp 434-445 (2021)

Abstract: Coronavirus disease 2019 (COVID‐19) is associated with adverse outcomes, including need for invasive mechanical ventilation and death in people with risk factors. Liver enzyme elevation is commonly seen in this group, but its clinical significance rema...

SARS-CoV-2 viral load is associated with increased disease severity and mortality

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)

Abstract: In this study, Massachusetts Consortium for Pathogen Readiness (MassCPR) investigators assess the relationship between SARS-CoV-2 viral load and COVID-19 disease severity and report that the levels of detectable viral RNA, especially in plasma, correla...


Viral Rebound Kinetics Correlate with Distinct HIV Antibody Features

Publication Type: Academic Journal

Source(s): mBio, Vol 12, Iss 2 (2021)

Abstract: Plasma viremia reoccurs in most HIV-infected individuals once antiretroviral therapy is interrupted, and interindividual differences in the kinetics of viral rebound have been associated with virological and immunological factors. Antibody features, in...


Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors.

Publication Type: Academic Journal

Source(s): PLoS Pathogens, Vol 17, Iss 2, p e1009165 (2021)

Abstract: The interactions between antibodies, SARS-CoV-2 and immune cells contribute to the pathogenesis of COVID-19 and protective immunity. To understand the differences between antibody responses in mild versus severe cases of COVID-19, we analyzed the B cel...

What is the Role of Kinesiophobia and Pain Catastrophizing in Outcomes After Hip Arthroscopy for Femoroacetabular Impingement Syndrome?

Publication Type: Academic Journal

Source(s): Arthroscopy, Sports Medicine, and Rehabilitation, Vol 2, Iss 2, Pp e97-e104 (2020)

Abstract: Purpose: To (1) investigate trends in kinesiophobia and pain catastrophizing after hip arthroscopy for femoroacetabular impingement syndrome (FAIS), and (2) determine whether kinesiophobia and pain catastrophizing scores are associated with achieving m...

A Sample-Sparing Multiplexed ADCP Assay

Publication Type: Academic Journal

Source(s): Frontiers in Immunology, Vol 10 (2019)

Abstract: Antibodies serve as the primary correlate of protection following most clinically approved vaccines and are thought to confer protection in part through their ability to block (neutralize) infection. Increasingly, studies have shown that beyond their b...

The Surprising Greatness of Jimmy Carter.

Publication Type: Periodical

Source(s): Washington Monthly; Nov/Dec2021, Vol. 53 Issue 11/12, p35-49, 15p, 9 Color Photographs, 2 Black and White Photographs, 1 Cartoon or Caricature

Abstract: The article presents the discussion on America's least-effective modern presidents blamed for failing to tame inflation, solving the energy crisis, or free the American hostages in Tehran including dangers of climate change.