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Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study
Publication Type: Academic Journal
Source(s): The Lancet Public Health, Vol 6, Iss 5, Pp e335-e345 (2021)
Abstract: Summary: Background: The SARS-CoV-2 variant B.1.1.7 was first identified in December, 2020, in England. We aimed to investigate whether increases in the proportion of infections with this variant are associated with differences in symptoms or disease c...
The mental health burden of racial and ethnic minorities during the COVID-19 pandemic.
Publication Type: Academic Journal
Source(s): PLoS ONE, Vol 17, Iss 8, p e0271661 (2022)
Abstract: Racial/ethnic minorities have been disproportionately impacted by COVID-19. The effects of COVID-19 on the long-term mental health of minorities remains unclear. To evaluate differences in odds of screening positive for depression and anxiety among var...
Genetic diversity fuels gene discovery for tobacco and alcohol use
Publication Type: Periodical
Source(s): Nature; December 2022, Vol. 612 Issue: 7941 p720-724, 5p
Abstract: Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury1–4. These substances are used across the globe, yet genome-wide association stud...
Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab
Publication Type: Periodical
Source(s): Circulation (Ovid); August 2022, Vol. 146 Issue: 9 p657-672, 16p
Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis
Publication Type: Periodical
Source(s): The Lancet Respiratory Medicine; April 2022, Vol. 10 Issue: 4 p367-377, 11p
Abstract: Two acute respiratory distress syndrome (ARDS) subphenotypes (hyperinflammatory and hypoinflammatory) with distinct clinical and biological features and differential treatment responses have been identified using latent class analysis (LCA) in seven in...
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Publication Type: Periodical
Source(s): The Lancet; February 2021, Vol. 397 Issue: 10274 p605-612, 8p
Abstract: Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants
Publication Type: Periodical
Source(s): The Lancet; November 2020, Vol. 396 Issue: 10261 p1511-1524, 14p
Abstract: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected f...
Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial
Publication Type: Periodical
Source(s): The Lancet; September-October 2019, Vol. 394 Issue: 10204 p1169-1180, 12p
Abstract: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In thi...
Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
Publication Type: Periodical
Source(s): The Lancet Diabetes & Endocrinology; August 2019, Vol. 7 Issue: 8 p618-628, 11p
Abstract: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4–1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome...
Overcoming NOTCH1-Driven Chemoresistance in T-Cell Acute Lymphoblastic Leukemia Via Metabolic Intervention with Oxphos Inhibitor
Publication Type: Periodical
Source(s): Blood; November 2020, Vol. 136 Issue: 1, Number 1 Supplement 1 p18-20, 3p
Abstract: The inferior cure rate of T-cell acute lymphoblastic leukemia (T-ALL) is associated with inherent drug resistance. The activating NOTCH1gene mutations have been reported to cause chemoresistance at the stem cell level1. Direct NOTCH1 inhibition has fai...