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Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke
Publication Type: Academic Journal
Source(s): Intensive Care Medicine Experimental, Vol 10, Iss 1, Pp 1-20 (2022)
Abstract: Abstract Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation. We compared the effects of the combination of mild hypother...
Investigating the role of the foveal cortex in peripheral object discrimination
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract: Abstract Peripheral object discrimination is hindered by a central dynamic mask presented between 150 and 300 ms after stimulus onset. The mask is thought to interfere with task-relevant feedback coming from higher visual areas to the foveal cortex in ...
econet: An R Package for Parameter-Dependent Network Centrality Measures
Publication Type: Academic Journal
Source(s): Journal of Statistical Software, Vol 102, Pp 1-30 (2022)
Abstract: The R package econet provides methods for estimating parameter-dependent network centrality measures with linear-in-means models. Both nonlinear least squares and maximum likelihood estimators are implemented. The methods allow for both link and node h...
Individualized positive end-expiratory pressure guided by end-expiratory lung volume in early acute respiratory distress syndrome: study protocol for the multicenter, randomized IPERPEEP trial
Publication Type: Academic Journal
Source(s): Trials, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract: Abstract Background In acute respiratory distress syndrome (ARDS), response to positive end-expiratory pressure (PEEP) is variable according to different degrees of lung recruitability. The search for a tool to individualize PEEP based on patients’ ind...
Neurological Manifestations of SARS-CoV-2 Infection: Protocol for a Sub-analysis of the COVID-19 Critical Care Consortium Observational Study
Publication Type: Academic Journal
Source(s): Frontiers in Medicine, Vol 9 (2022)
Abstract: IntroductionNeurological manifestations and complications in coronavirus disease-2019 (COVID-19) patients are frequent. Prior studies suggested a possible association between neurological complications and fatal outcome, as well as the existence of pot...
Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract: Abstract Acute ischemic stroke is associated with pulmonary complications, and often dexmedetomidine and propofol are used to decrease cerebral metabolic rate. However, it is unknown the immunomodulatory actions of dexmedetomidine and propofol on brain...
Assessment of 28-Day In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019: An International Cohort Study
Publication Type: Academic Journal
Source(s): Critical Care Explorations, Vol 3, Iss 11, p e0567 (2021)
Abstract: IMPORTANCE:. Factors associated with mortality in coronavirus disease 2019 patients on invasive mechanical ventilation are still not fully elucidated. OBJECTIVES:. To identify patient-level parameters, readily available at the bedside, associated with ...
Ten golden rules for individualized mechanical ventilation in acute respiratory distress syndrome
Publication Type: Academic Journal
Source(s): Journal of Intensive Medicine, Vol 1, Iss 1, Pp 42-51 (2021)
Abstract: Considerable progress has been made over the last decades in the management of acute respiratory distress syndrome (ARDS). Mechanical ventilation(MV) remains the cornerstone of supportive therapy for ARDS. Lung-protective MV minimizes the risk of venti...
The spatio-temporal relationship between white matter lesion volume changes and brain atrophy in clinically isolated syndrome and early multiple sclerosis
Publication Type: Academic Journal
Source(s): NeuroImage: Clinical, Vol 36, Iss , Pp 103220- (2022)
Abstract: Background: White matter lesions and brain atrophy are both present early in multiple sclerosis. However, the spatio-temporal relationship between atrophy and lesion processes remains unclear. Methods: Yearly magnetic resonance images were analyzed in ...
MAGNIMS recommendations for harmonization of MRI data in MS multicenter studies
Publication Type: Academic Journal
Source(s): NeuroImage: Clinical, Vol 34, Iss , Pp 102972- (2022)
Abstract: There is an increasing need of sharing harmonized data from large, cooperative studies as this is essential to develop new diagnostic and prognostic biomarkers. In the field of multiple sclerosis (MS), the issue has become of paramount importance due t...