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Advanced Search Results For "Bai, Jiale"

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 "Bai, Jiale"
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Long-course chemoradiation plus concurrent/sequential PD-1 blockade as neoadjuvant treatment for MMR-status-unscreened locally advanced rectal cancer: protocol of a multicentre, phase 2, randomised controlled trial (the POLAR-STAR trial)

Publication Type: Academic Journal

Source(s): BMJ Open, Vol 13, Iss 9 (2023)

Abstract: Introduction Recent preclinical studies have discovered unique synergism between radiotherapy and immune checkpoint inhibitors, which has already brought significant survival benefit in lung cancer. In locally advanced rectal cancer (LARC), neoadjuvant...


Transcriptome and digital gene expression analysis reveal immune responses of mantle and visceral mass pearl culturing in Hyriopsis cumingii

Publication Type: Academic Journal

Source(s): Frontiers in Marine Science, Vol 10 (2023)

Abstract: Biomineralization is a widespread phenomenon in marine mollusks and is responsible for the production of shells and pearls. However, the regulatory mechanisms governing the adaptive immune responses in the mollusk mantle and visceral mass during minera...

Analysis of Tooth Profile Characteristics and Meshing Characteristics of Double Cycloid Needle Tooth Transmission

Publication Type: Academic Journal

Source(s): Jixie chuandong, Pp 1-8 (2023)

Abstract: In order to solve the problems of the traditional output structure of the cycloid pinion transmission, such as easy damage and complex structure, a new type of cycloid pinion gear is proposed by applying the internal and external cycloid tooth profile ...

Effect and mechanism of apelin on lipopolysaccharide induced acute pulmonary vascular endothelial barrier dysfunction

Publication Type: Academic Journal

Source(s): Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract: Abstract Vascular endothelial barrier dysfunction is the most prominent manifestation and important cause of mortality in infectious acute lung injury (ALI). Exogenous apelin is effective in ameliorating lipopolysaccharide (LPS)-induced inflammatory re...


Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies

Publication Type: Academic Journal

Source(s): Biomaterials Research, Vol 26, Iss 1, Pp 1-33 (2022)

Abstract: Abstract Implant-associated infection (IAI) is increasingly emerging as a serious threat with the massive application of biomaterials. Bacteria attached to the surface of implants are often difficult to remove and exhibit high resistance to bactericide...

Identification of the RNA-binding domain-containing protein RbpA that acts as a global regulator of the pathogenicity of Streptococcus suis serotype 2

Publication Type: Academic Journal

Source(s): Virulence, Vol 13, Iss 1, Pp 1304-1314 (2022)

Abstract: Streptococcus suis serotype 2 (SS2), an emerging zoonotic pathogen, causes swine diseases and human cases of streptococcal toxic shock syndrome. RNA-binding proteins (RBPs) can modulate gene expression through post-transcriptional regulation. In this s...

Interim result of phase II, prospective, single-arm trial of long-course chemoradiotherapy combined with concurrent tislelizumab in locally advanced rectal cancer

Publication Type: Academic Journal

Source(s): Frontiers in Oncology, Vol 13 (2023)

Abstract: BackgroundNeoadjuvant chemoradiotherapy is the standard treatment for locally advanced rectal cancer, with modest benefits on tumor regression and survival. Since chemoradiotherapy combined with immune checkpoint inhibitors has been reported to have sy...

Recent advances in responsive hydrogels for diabetic wound healing

Publication Type: Academic Journal

Source(s): Materials Today Bio, Vol 18, Iss , Pp 100508- (2023)

Abstract: Poor wound healing after diabetes mellitus remains a challenging problem, and its pathophysiological mechanisms have not yet been fully elucidated. Persistent bleeding, disturbed regulation of inflammation, blocked cell proliferation, susceptible infec...

Analysis of protein kinase C (HcPKC) gene expression and single-nucleotide polymorphisms related to inner shell color traits in Hyriopsis cumingii

Publication Type: Academic Journal

Source(s): BMC Genomic Data, Vol 23, Iss 1, Pp 1-10 (2022)

Abstract: Abstract Background Protein kinase C (PKC) is a multifunctional serine and PKC can phosphorylate serine residues in the cytoplasmic domain of tyrosinase, thereby regulating the activity of tyrosinase. Activated PKC is bound to the melanosome membrane, ...

Effect of Arabinoxylan from Wastewater Generated during Vital Wheat Gluten Production on Liver Metabolism in Type 2 Diabetic Mice

Publication Type: Academic Journal

Source(s): Foods, Vol 12, Iss 2640, p 2640 (2023)

Abstract: Arabinoxylan (AX) is a dietary fiber that has been proven to have a significant antidiabetic effect. Liver metabolic disorders frequently coincide with the development of type 2 diabetes, but research on the hepatoprotective effects of AX in type 2 dia...