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Advanced Search Results For "Baker, Joel E."

1 - 10 of 426 results for
 "Baker, Joel E."
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Precision health diagnostic and surveillance network uses S gene target failure (SGTF) combined with sequencing technologies to track emerging SARS‐CoV‐2 variants

Publication Type:Academic Journal

Source(s):Immunity, Inflammation and Disease, Vol 10, Iss 6, Pp n/a-n/a (2022)

Abstract:Abstract Introduction The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic revealed a worldwide lack of effective molecular surveillance networks at local, state, and national levels, which are essential to identify, monitor, and l...

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Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Abstract:Here, the authors present cryoEMPEM, a method for high-resolution structural analysis of vaccine-elicited polyclonal antibody responses. They apply cryoEMPEM in combination with standard serology experiments to characterize the polyclonal antibody (pAb...

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The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Publication Type:Academic Journal

Source(s):iScience, Vol 24, Iss 11, Pp 103353- (2021)

Abstract:Summary: We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of reco...

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Access to and safety of COVID-19 convalescent plasma in the United States Expanded Access Program: A national registry study.

Publication Type:Academic Journal

Source(s):PLoS Medicine, Vol 18, Iss 12, p e1003872 (2021)

Abstract:BackgroundThe United States (US) Expanded Access Program (EAP) to coronavirus disease 2019 (COVID-19) convalescent plasma was initiated in response to the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent...

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Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Abstract:There is strong genetic evidence for cigarette smoking behaviors, yet little is known on nicotine dependence (ND). Here, the authors perform a genome-wide association study on ND in 58,000 smokers, identifying five genome-wide significant loci.

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The genomic epidemiology of multi-drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries

Publication Type:Academic Journal

Source(s):BMJ Global Health, Vol 6, Iss 8 (2021)

Abstract:Background Invasive non-typhoidal Salmonella (iNTS) is one of the leading causes of bacteraemia in sub-Saharan Africa. We aimed to provide a better understanding of the genetic characteristics and transmission patterns associated with multi-drug resist...

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Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7

Publication Type:Academic Journal

Source(s):Cell Reports, Vol 35, Iss 13, Pp 109292- (2021)

Abstract:Summary: We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding...

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Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study

Publication Type:Academic Journal

Source(s):The Lancet Public Health, Vol 6, Iss 5, Pp e335-e345 (2021)

Abstract:Summary: Background: The SARS-CoV-2 variant B.1.1.7 was first identified in December, 2020, in England. We aimed to investigate whether increases in the proportion of infections with this variant are associated with differences in symptoms or disease c...

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Circulating sex hormone binding globulin levels are modified with intensive lifestyle intervention, but their changes did not independently predict diabetes risk in the Diabetes Prevention Program

Publication Type:Academic Journal

Source(s):BMJ Open Diabetes Research & Care, Vol 8, Iss 2 (2020)

Abstract:Introduction Sex hormone binding globulin (SHBG) levels are reported to be inversely associated with diabetes risk. It is unknown whether diabetes prevention interventions increase SHBG and whether resultant changes in SHBG affect diabetes risk. The pu...

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International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

Abstract:Post-traumatic stress disorder (PTSD) is a common mental health problem. Here, the authors report a GWAS from the Psychiatric Genomics Consortium in which they identify two risk loci in European ancestry and one locus in African ancestry individuals an...

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