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Advanced Search Results For "Boyd, R. Justin"

1 - 10 of 157 results for
 "Boyd, R. Justin"
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Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Publication Type: Academic Journal

Source(s): The Lancet Global Health, Vol 10, Iss 7, Pp e1003-e1011 (2022)

Abstract: Summary: Background: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of ...

Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units

Publication Type: Academic Journal

Source(s): Genome Medicine, Vol 13, Iss 1, Pp 1-16 (2021)

Abstract: Abstract Background Clinical metagenomics (CMg) has the potential to be translated from a research tool into routine service to improve antimicrobial treatment and infection control decisions. The SARS-CoV-2 pandemic provides added impetus to realise t...

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Publication Type: Academic Journal

Source(s): iScience, Vol 24, Iss 11, Pp 103353- (2021)

Abstract: Summary: We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of reco...

Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 35, Iss 13, Pp 109292- (2021)

Abstract: Summary: We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding...

Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study

Publication Type: Academic Journal

Source(s): The Lancet Public Health, Vol 6, Iss 5, Pp e335-e345 (2021)

Abstract: Summary: Background: The SARS-CoV-2 variant B.1.1.7 was first identified in December, 2020, in England. We aimed to investigate whether increases in the proportion of infections with this variant are associated with differences in symptoms or disease c...

Phosphorylation state of the histone variant H2A.X controls human stem and progenitor cell fate decisions

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 34, Iss 10, Pp 108818- (2021)

Abstract: Summary: Histone variants (HVs) are a subfamily of epigenetic regulators implicated in embryonic development, but their role in human stem cell fate remains unclear. Here, we reveal that the phosphorylation state of the HV H2A.X (γH2A.X) regulates self...

Circulating sex hormone binding globulin levels are modified with intensive lifestyle intervention, but their changes did not independently predict diabetes risk in the Diabetes Prevention Program

Publication Type: Academic Journal

Source(s): BMJ Open Diabetes Research & Care, Vol 8, Iss 2 (2020)

Abstract: Introduction Sex hormone binding globulin (SHBG) levels are reported to be inversely associated with diabetes risk. It is unknown whether diabetes prevention interventions increase SHBG and whether resultant changes in SHBG affect diabetes risk. The pu...

Low-Level Mouse DNA in Conditioned Medium Generates False Positive Cross-Species Contamination Results in Human Organoid Cultures

Publication Type: Academic Journal

Source(s): Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Abstract: Cell line authentication is critical for preventing the use of mixed or misidentified cell lines in research. Current efforts include short tandem repeat (STR) analysis and PCR-based assays to detect mixed species cultures. Using PCR analysis with mous...

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Abstract: The optimal Aβ species to target for the potential treatment of Alzheimer’s disease has not yet been established. Here, the authors describe an in vitro assay that uses extracts from brain tissue from patients with Alzheimer’s disease, and application ...


Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons

Publication Type: Academic Journal

Source(s): Neurobiology of Disease, Vol 111, Iss , Pp 26-35 (2018)

Abstract: Missense mutations in the multi-domain kinase LRRK2 cause late onset familial Parkinson's disease. They most commonly with classic proteinopathy in the form of Lewy bodies and Lewy neurites comprised of insoluble α-synuclein, but in rare cases can also...