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    • Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease.

    Publication Type: Academic Journal

    Source(s): Journal of Medicinal Chemistry; 9/28/2023, Vol. 66 Issue 18, p13205-13246, 42p

    Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology.

    Publication Type: Academic Journal

    Source(s): Journal of Medicinal Chemistry; 9/22/2022, Vol. 65 Issue 18, p12445-12459, 15p

    Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington’s Disease

    Publication Type: Periodical

    Source(s): Journal of Medicinal Chemistry; April 2021, Vol. 64 Issue: 8 p5018-5036, 19p

    Abstract: Our group has recently shown that brain-penetrant ataxia telangiectasia-mutated (ATM) kinase inhibitors may have potential as novel therapeutics for the treatment of Huntington’s disease (HD). However, the previously described pyranone-thioxanthenes (e...

    Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models.

    Publication Type: Academic Journal

    Source(s): Journal of Medicinal Chemistry; 3/28/2019, Vol. 62 Issue 6, p2988-3008, 21p

    Inter- and Intramolecular Annulation Strategies toa Cyclopentanone Building Block Containing an All-Carbon QuaternaryStereogenic Center.

    Publication Type: Academic Journal

    Source(s): Organic Letters; Mar2015, Vol. 17 Issue 6, p1401-1404, 4p

    Enantioselective Transport by a Steroidal Guanidinium Receptor.

    Publication Type: Academic Journal

    Source(s): Chemistry - A European Journal; Jul2002, Vol. 8 Issue 13, p2931-2936, 6p

    In silico scaffold evaluation and solid phase approach to identify new gelatinase inhibitors

    Publication Type: Academic Journal

    Source(s): Bioorganic & Medicinal Chemistry. Apr2012, Vol. 20 Issue 7, p2323-2337. 15p.

    Abstract: Abstract: Among matrix metalloproteinases (MMPs), gelatinases MMP-2 (gelatinase A) and MMP-9 (gelatinase B) play a key role in a number of physiological processes such as tissue repair and fibrosis. Many evidences point out their involvement in a serie...

    Guanidinium Receptors as Enantioselective Amino Acid Membrane Carriers.

    Publication Type: Academic Journal

    Source(s): Journal of the American Chemical Society. 7/9/2003, Vol. 125 Issue 27, p8270. 15p. 6 Diagrams, 5 Charts, 2 Graphs.

    Abstract: A number of artificial carriers for the transport of zwitterionic aromatic amino acids across bulk model membranes (U-tube type) have been prepared and evaluated. 1,2-Dichloroethane and dichloromethane were employed in the organic phase. All compounds ...

    Alkaline-earth metal complexes of thiol-pendant crown ethers as turnover catalysts of ester cleavage

    Publication Type: Periodical

    Source(s): Journal of the Chemical Society, Perkin Transactions 2; May 1, 1998, Vol. 1998 Issue: 5 p1257-1262, 6p

    Abstract: Methanolysis of pNPOAc under moderately alkaline conditions is catalysed by the alkaline-earth metal ion (Ca, Sr, Ba) complexes of 2-(mercaptomethyl)-18-crown-6 according to biphasic kinetics in which an initial burst of pNPOH release is followed by a ...

    Thiopyrophosphoantigens: Solid-phase Synthesis and in Vitro Characterization of a New Class of Vγ9 Vδ2 T Cells Activators.

    Publication Type: Academic Journal

    Source(s): Journal of Medicinal Chemistry; Jun2009, Vol. 52 Issue 12, p3716-3722, 7p

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