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Advanced Search Results For "Brown, John H."

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 "Brown, John H."
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Regulome analysis in B-acute lymphoblastic leukemia exposes Core Binding Factor addiction as a therapeutic vulnerability

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Abstract: The ETV6-RUNX1 chimeric- and native RUNX1-responsive regulomes in paediatric B-acute lymphoblastic leukemia (B-ALL) remain to be characterized. Here, the authors reveal functional antagonism between the two transcription factors predominantly for the r...


Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort studyResearch in context

Publication Type: Academic Journal

Source(s): EClinicalMedicine, Vol 55, Iss , Pp 101724- (2023)

Abstract: Summary: Background: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking. Methods: A retrospective multi-centr...

Temporal patterns in coral reef fish assemblages with varying disturbance levels: A tale of two National Parks in Hawai´i

Publication Type: Academic Journal

Source(s): Frontiers in Marine Science, Vol 9 (2022)

Abstract: Long-term ecological monitoring of coral reefs can reveal the state of the reef communities and responses of different reef components to various pulse and press disturbance events. Here, we describe long-term monitoring of reef fish assemblages from t...

Design-development of an at-home modular brain–computer interface (BCI) platform in a case study of cervical spinal cord injury

Publication Type: Academic Journal

Source(s): Journal of NeuroEngineering and Rehabilitation, Vol 19, Iss 1, Pp 1-14 (2022)

Abstract: Abstract Objective The objective of this study was to develop a portable and modular brain–computer interface (BCI) software platform independent of input and output devices. We implemented this platform in a case study of a subject with cervical spina...

Injectable Nanoparticle‐Based Hydrogels Enable the Safe and Effective Deployment of Immunostimulatory CD40 Agonist Antibodies

Publication Type: Academic Journal

Source(s): Advanced Science, Vol 9, Iss 28, Pp n/a-n/a (2022)

Abstract: Abstract When properly deployed, the immune system can eliminate deadly pathogens, eradicate metastatic cancers, and provide long‐lasting protection from diverse diseases. Unfortunately, realizing these remarkable capabilities is inherently risky as di...

Impact of Perineuronal Net Removal in the Rat Medial Prefrontal Cortex on Parvalbumin Interneurons After Reinstatement of Cocaine Conditioned Place Preference

Publication Type: Academic Journal

Source(s): Frontiers in Cellular Neuroscience, Vol 16 (2022)

Abstract: Parvalbumin (PV)-positive cells are GABAergic fast-spiking interneurons that modulate the activity of pyramidal neurons in the medial prefrontal cortex (mPFC) and their output to brain areas associated with learning and memory. The majority of PV cells...

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Publication Type: Academic Journal

Source(s): iScience, Vol 24, Iss 11, Pp 103353- (2021)

Abstract: Summary: We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of reco...

Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)

Abstract: Recurrent glioblastomas (rGBM) have dismal outcomes, but long-term survival has been observed in subsets of patients after immunotherapy. Here the authors report a positive association between low tumor mutation burden, inflammatory gene signatures, an...


Following the edge of the flood: use of shallow-water habitat by larval silver carp Hypophthalmichthys molitrix in the upper Mississippi river system

Publication Type: Academic Journal

Source(s): Journal of Freshwater Ecology, Vol 35, Iss 1, Pp 95-104 (2020)

Abstract: We examined the use of “edge of flood” habitats by larval silver carp during the extensive flooding that occurred in Pool 26 of the Upper Mississippi River near Alton, IL, USA and St. Louis, MO, USA during the summer of 2015. We captured over 12,700 in...