Advanced Search Results For "Bruijn, Michelle"
Your filters
Association of Ischemic Core Imaging Biomarkers With Post-Thrombectomy Clinical Outcomes in the MR CLEAN Registry
Publication Type: Academic Journal
Source(s): Frontiers in Neurology, Vol 12 (2022)
Abstract: Background: A considerable proportion of acute ischemic stroke patients treated with endovascular thrombectomy (EVT) are dead or severely disabled at 3 months despite successful reperfusion. Ischemic core imaging biomarkers may help to identify patient...
"No drugs in my back yard:" The ambivalent reception of cannabis retailers.
Publication Type: Academic Journal
Source(s): Journal of Economic Behavior & Organization. Jul2022, Vol. 199, p103-121. 19p.
Abstract: Can individuals' aversion to drug markets curb the benefits of decriminalization? We investigate the effect of two policies on housing demand in the Netherlands: the distance-to-school criterion, which closed some cannabis shops in a few cities; and th...
Genome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract: Abstract Identifying single nucleotide polymorphisms (SNPs) that influence chemotherapy disposition may help to personalize cancer treatment and limit toxicity. Genome-wide approaches are unbiased, compared with candidate gene studies, but usually requ...
The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
Publication Type: Academic Journal
Source(s): Cell Reports, Vol 23, Iss 1, Pp 313-326.e5 (2018)
Abstract: Summary: Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic sub...
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers
Publication Type: Academic Journal
Source(s): Cell Reports, Vol 23, Iss 1, Pp 227-238.e3 (2018)
Abstract: Summary: Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% ...
Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images
Publication Type: Academic Journal
Source(s): Cell Reports, Vol 23, Iss 1, Pp 181-193.e7 (2018)
Abstract: Summary: Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images f...
Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers
Publication Type: Academic Journal
Source(s): Cell Reports, Vol 23, Iss 1, Pp 255-269.e4 (2018)
Abstract: Summary: Metabolic reprogramming provides critical information for clinical oncology. Using molecular data of 9,125 patient samples from The Cancer Genome Atlas, we identified tumor subtypes in 33 cancer types based on mRNA expression patterns of seven...
Systematic Analysis of Splice-Site-Creating Mutations in Cancer
Publication Type: Academic Journal
Source(s): Cell Reports, Vol 23, Iss 1, Pp 270-281.e3 (2018)
Abstract: Summary: For the past decade, cancer genomic studies have focused on mutations leading to splice-site disruption, overlooking those having splice-creating potential. Here, we applied a bioinformatic tool, MiSplice, for the large-scale discovery of spli...
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
Publication Type: Academic Journal
Source(s): Cell Reports, Vol 23, Iss 1, Pp 239-254.e6 (2018)
Abstract: Summary: DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations with accompanying ...
Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types
Publication Type: Academic Journal
Source(s): Cell Reports, Vol 23, Iss 1, Pp 282-296.e4 (2018)
Abstract: Summary: Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer. We analyzed whole-exome sequencing data across 33 tumor types in The C...