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Advanced Search Results For "Butler, Michael J."

1 - 10 of 3,208 results for
 "Butler, Michael J."
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Cross-species comparisons reveal resistance of human skeletal stem cells to inhibition by non-steroidal anti-inflammatory drugs

Publication Type:Academic Journal

Source(s):Frontiers in Endocrinology, Vol 13 (2022)

Abstract:Fracture healing is highly dependent on an early inflammatory response in which prostaglandin production by cyclo-oxygenases (COX) plays a crucial role. Current patient analgesia regimens favor opioids over Non-Steroidal Anti-Inflammatory Drugs (NSAIDs...

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Analysis of X‐inactivation status in a Rett syndrome natural history study cohort

Publication Type:Academic Journal

Source(s):Molecular Genetics & Genomic Medicine, Vol 10, Iss 5, Pp n/a-n/a (2022)

Abstract:Abstract Background Rett syndrome (RTT) is a rare neurodevelopmental disorder associated with pathogenic MECP2 variants. Because the MECP2 gene is subject to X‐chromosome inactivation (XCI), factors including MECP2 genotypic variation, tissue differenc...

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The role of Western diets and obesity in peripheral immune cell recruitment and inflammation in the central nervous system

Publication Type:Academic Journal

Source(s):Brain, Behavior, & Immunity - Health, Vol 16, Iss , Pp 100298- (2021)

Abstract:As the prevalence of obesity and chronic disease increases, the role of nutrition is taking center stage as a potential root cause of not just metabolic-related illnesses, but also of disorders of the central nervous system (CNS). Consumption of a mode...

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In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Abstract:During repair, development, or cancer metastasis, epithelial cells can become migratory through partial or full epithelial to mesenchymal transition (EMT). Here, the authors report that differentiated epithelial collectives may undergo cooperative and ...

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CANDIED: A Pan-Canadian Cohort of Immune Checkpoint Inhibitor-Induced Insulin-Dependent Diabetes Mellitus

Publication Type:Academic Journal

Source(s):Cancers, Vol 14, Iss 89, p 89 (2021)

Abstract:Immune checkpoint inhibitor (ICI)-induced insulin-dependent diabetes mellitus (IDDM) is a rare but potentially fatal immune-related adverse event (irAE). In this multicentre retrospective cohort study, we describe the characteristics of ICI-induced IDD...

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Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study

Publication Type:Academic Journal

Source(s):Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 7 (2021)

Abstract:Background Although Black adults are more likely to die from coronary heart disease (CHD) compared with White adults, few studies have examined the relationship between cigarette smoking and CHD risk among Black adults. We evaluated the relationship be...

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Assessing Potential Safety Zone Suitability Using a New Online Mapping Tool

Publication Type:Academic Journal

Source(s):Fire, Vol 5, Iss 5, p 5 (2022)

Abstract:Safety zones (SZs) are critical tools that can be used by wildland firefighters to avoid injury or fatality when engaging a fire. Effective SZs provide safe separation distance (SSD) from surrounding flames, ensuring that a fire’s heat cannot cause bur...

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Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)

Abstract:Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppres...

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Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia

Publication Type:Academic Journal

Source(s):eLife, Vol 9 (2020)

Abstract:Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis r...

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Assessing Lymphatic Uptake of Lipids Using Magnetic Resonance Imaging: A Feasibility Study in Healthy Human Volunteers with Potential Application for Tracking Lymph Node Delivery of Drugs and Formulation Excipients

Publication Type:Academic Journal

Source(s):Pharmaceutics, Vol 13, Iss 1343, p 1343 (2021)

Abstract:Dietary lipids and some pharmaceutical lipid excipients can facilitate the targeted delivery of drugs to the intestinal lymphatics. Here, the feasibility of magnetic resonance imaging (MRI) for imaging lipid uptake into the intestinal lymphatics was as...

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