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The relationship between the modified frailty index score (mFI-5), malnutrition, body composition, systemic inflammation and short-term clinical outcomes in patients undergoing surgery for colorectal cancer
Publication Type: Academic Journal
Source(s): BMC Geriatrics, Vol 23, Iss 1, Pp 1-8 (2023)
Abstract: Abstract Background While the current literature suggests an association with frailty and clinical outcomes in patients undergoing surgery for colorectal cancer (CRC), the basis of this relationship is unclear. Aim Examine the relationship between frai...
Association of body mass index with outcomes in patients with newly diagnosed atrial fibrillation: GARFIELD-AF
Publication Type: Academic Journal
Source(s): Open Heart, Vol 9, Iss 2 (2022)
Abstract: Objective While greater body mass index (BMI) is associated with increased risk of developing atrial fibrillation (AF), the impact of BMI on outcomes in newly diagnosed AF is unclear. We examine the influence of BMI on outcomes and whether this is modi...
Limited phylogeographic and genetic connectivity in Acacia species of low stature in an arid landscape
Publication Type: Academic Journal
Source(s): Ecology and Evolution, Vol 12, Iss 7, Pp n/a-n/a (2022)
Abstract: Abstract Widespread plant species are expected to maintain genetic diversity and gene flow via pollen and seed dispersal. Stature is a key life history trait that affects seed and potentially pollen dispersal, with limited stature associated with limit...
Liquid Biopsy: A Multi-Parametric Analysis of Mutation Status, Circulating Tumor Cells and Inflammatory Markers in EGFR-Mutated NSCLC
Publication Type: Academic Journal
Source(s): Diagnostics, Vol 12, Iss 2360, p 2360 (2022)
Abstract: The liquid biopsy has the potential to improve patient care in the diagnostic and therapeutic setting in non-small cell lung cancer (NSCLC). Consented patients with epidermal growth factor receptor (EGFR) positive disease (n = 21) were stratified into ...
MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Abstract: MDC1 and H2AX interact and accumulate at sites of DNA damage, functioning to recruit additional factors involved in the repair process. Here the authors uncover a function for MDC1 that is independent of the presence of H2AX and is mediated through its...
ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Abstract: Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. Here, the authors provide evidence that these hypersensitivities reflect a crucial role for ATM at damaged replication forks being to prevent to...
Machine Learning Predicts Prolonged Acute Hypoxemic Respiratory Failure in Pediatric Severe Influenza
Publication Type: Academic Journal
Source(s): Critical Care Explorations, Vol 2, Iss 8, p e0175 (2020)
Abstract: Background:. Influenza virus is a major cause of acute hypoxemic respiratory failure. Early identification of patients who will suffer severe complications can help stratify patients for clinical trials and plan for resource use in case of pandemic. Ob...
Behavioural activation therapy for post-stroke depression: the BEADS feasibility RCT
Publication Type: Academic Journal
Source(s): Health Technology Assessment, Vol 23, Iss 47 (2019)
Abstract: Background: There is currently insufficient evidence for the clinical effectiveness and cost-effectiveness of psychological therapies for post-stroke depression. Objective: To evaluate the feasibility of undertaking a definitive trial to evaluate the c...
Extensive Genetic Connectivity and Historical Persistence Are Features of Two Widespread Tree Species in the Ancient Pilbara Region of Western Australia
Publication Type: Academic Journal
Source(s): Genes, Vol 11, Iss 863, p 863 (2020)
Abstract: Phylogeographic studies can be used as a tool to understand the evolutionary history of a landscape, including the major drivers of species distributions and diversity. Extensive research has been conducted on phylogeographic patterns of species found ...
The skin transcriptome in hidradenitis suppurativa uncovers an antimicrobial and sweat gland gene signature which has distinct overlap with wounded skin.
Publication Type: Academic Journal
Source(s): PLoS ONE, Vol 14, Iss 5, p e0216249 (2019)
Abstract: Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease resulting in non-healing wounds affecting body areas of high hair follicle and sweat gland density. The pathogenesis of HS is not well understood but appears to involve d...