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Advanced Search Results For "Calmiano M"

1 - 10 of 5 results for
 "Calmiano M"
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Discovery of 4-azaindoles as novel inhibitors of c-Met kinase

Publication Type:Academic Journal

Source(s):Bioorganic & Medicinal Chemistry Letters. May2009, Vol. 19 Issue 10, p2780-2784. 5p.

Abstract:Abstract: A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and series optimisation was performed on the basis of this structure. Future directions for series develo...

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Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase

Publication Type:Academic Journal

Source(s):Bioorganic & Medicinal Chemistry Letters. Jan2009, Vol. 19 Issue 2, p397-400. 4p.

Abstract:Abstract: A series of quinoxaline inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and optimisation of the series was performed on the basis of this structure. Future directions for develo...

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A white-knuckle ride of open COVID drug discovery.

Publication Type:Academic Journal

Source(s):Nature [Nature] 2021 Jun; Vol. 594 (7863), pp. 330-332.

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Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo.

Publication Type:Academic Journal

Source(s):Journal of medicinal chemistry [J Med Chem] 2018 Aug 09; Vol. 61 (15), pp. 6705-6723. Date of Electronic Publication: 2018 Jul 19.

Abstract:The primary target of a novel series of immunosuppressive 7-piperazin-1-ylthiazolo[5,4- d]pyrimidin-5-amines was identified as the lipid kinase, PI4KIIIβ. Evaluation of the series highlighted their poor solubility and unwanted off-target activities. A ...

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Natural Conformational Sampling of Human TNFα Visualized by Double Electron-Electron Resonance.

Publication Type:Academic Journal

Source(s):Biophysical journal [Biophys J] 2017 Jul 25; Vol. 113 (2), pp. 371-380.

Abstract:Double electron-electron resonance in conjunction with site-directed spin labeling has been used to probe natural conformational sampling of the human tumor necrosis factor α trimer. We suggest a previously unreported, predeoligomerization conformation...

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