Advanced Search Results For "Chaffee KG"
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Targeting an alternate Wilms' tumor antigen 1 peptide bypasses immunoproteasome dependency.
Publication Type: Academic Journal
Source(s): Science translational medicine [Sci Transl Med] 2022 Feb 09; Vol. 14 (631), pp. eabg8070. Date of Electronic Publication: 2022 Feb 09.
Abstract: Designing effective antileukemic immunotherapy will require understanding mechanisms underlying tumor control or resistance. Here, we report a mechanism of escape from immunologic targeting in an acute myeloid leukemia (AML) patient, who relapsed 1 yea...
Oral Health Birth Cohort Studies: Achievements, Challenges, and Potential.
Publication Type: Academic Journal
Source(s): Journal of dental research [J Dent Res] 2020 Nov; Vol. 99 (12), pp. 1321-1331. Date of Electronic Publication: 2020 Jul 17.
Abstract: Birth cohorts are those among observational studies that provide understanding of the natural history and causality of diseases since early in life. Discussions during an International Association for Dental Research symposium in London, United Kingdom...
Analysis of Heritability and Genetic Architecture of Pancreatic Cancer: A PanC4 Study.
Publication Type: Academic Journal
Source(s): Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2019 Jul; Vol. 28 (7), pp. 1238-1245. Date of Electronic Publication: 2019 Apr 23.
Abstract: Background: Pancreatic cancer is the fourth-leading cause of cancer death in both men and women in the United States. The currently identified common susceptibility loci account for a small fraction of estimated heritability. We sought to estimate over...
Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.
Publication Type: Academic Journal
Source(s): Journal of the National Cancer Institute [J Natl Cancer Inst] 2019 Jun 01; Vol. 111 (6), pp. 557-567.
Abstract: Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a p...
Risk of Different Cancers Among First-degree Relatives of Pancreatic Cancer Patients: Influence of Probands' Susceptibility Gene Mutation Status.
Publication Type: Academic Journal
Source(s): Journal of the National Cancer Institute [J Natl Cancer Inst] 2019 Mar 01; Vol. 111 (3), pp. 264-271.
Abstract: Background: Increased risk of malignancies other than pancreatic cancer (PC) has been reported among first-degree relatives (FDRs) of PC patients; however, the roles of susceptibility gene mutations are unclear. We assessed risk for 15 cancers among FD...
Should Researchers Offer Results to Family Members of Cancer Biobank Participants? A Mixed-Methods Study of Proband and Family Preferences.
Publication Type: Academic Journal
Source(s): AJOB empirical bioethics [AJOB Empir Bioeth] 2019 Jan-Mar; Vol. 10 (1), pp. 1-22. Date of Electronic Publication: 2018 Dec 31.
Abstract: Background: Genomic analysis may reveal both primary and secondary findings with direct relevance to the health of probands' biological relatives. Researchers question their obligations to return findings not only to participants but also to family mem...
Chronic lymphocytic leukemia cells from ibrutinib treated patients are sensitive to Axl receptor tyrosine kinase inhibitor therapy.
Publication Type: Academic Journal
Source(s): Oncotarget [Oncotarget] 2018 Dec 14; Vol. 9 (98), pp. 37173-37184. Date of Electronic Publication: 2018 Dec 14 (Print Publication: 2018).
Abstract: Earlier we have shown the expression of a constitutively active receptor tyrosine kinase Axl in CLL B-cells from previously untreated CLL patients, and that Axl inhibitor TP-0903 induces robust leukemic B-cell death. To explore whether Axl is an effect...
CDKN2A Germline Rare Coding Variants and Risk of Pancreatic Cancer in Minority Populations.
Publication Type: Academic Journal
Source(s): Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2018 Nov; Vol. 27 (11), pp. 1364-1370. Date of Electronic Publication: 2018 Jul 23.
Abstract: Background: Pathogenic germline mutations in the CDKN2A tumor suppressor gene are rare and associated with highly penetrant familial melanoma and pancreatic cancer in non-Hispanic whites (NHW). To date, the prevalence and impact of CDKN2A rare coding v...
Autoimmune cytopenias in patients with chronic lymphocytic leukaemia treated with ibrutinib in routine clinical practice at an academic medical centre.
Publication Type: Academic Journal
Source(s): British journal of haematology [Br J Haematol] 2018 Nov; Vol. 183 (3), pp. 421-427. Date of Electronic Publication: 2018 Aug 16.
Abstract: The effects of ibrutinib on the natural history of autoimmune cytopenias (AIC) among chronic lymphocytic leukaemia (CLL) patients treated in routine clinical practice require further investigation. Using the Mayo Clinical CLL Database, 193 CLL patients...
Immunoglobulin heavy chain variable region gene and prediction of time to first treatment in patients with chronic lymphocytic leukemia: Mutational load or mutational status? Analysis of 1003 cases.
Publication Type: Report
Source(s): American journal of hematology [Am J Hematol] 2018 Sep; Vol. 93 (9), pp. E216-E219. Date of Electronic Publication: 2018 Jul 30.