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Advanced Search Results For "Cheng, Jason M. K."

1 - 10 of 487 results for
 "Cheng, Jason M. K."
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SARS-CoV-2 infection in Africa: a systematic review and meta-analysis of standardised seroprevalence studies, from January 2020 to December 2021

Publication Type:Academic Journal

Source(s):BMJ Global Health, Vol 7, Iss 8 (2022)

Abstract:Introduction Estimating COVID-19 cumulative incidence in Africa remains problematic due to challenges in contact tracing, routine surveillance systems and laboratory testing capacities and strategies. We undertook a meta-analysis of population-based se...

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Refractive Growth of the Crystalline Lens in the Infant Aphakia Treatment Study

Publication Type:Academic Journal

Source(s):Ophthalmology Science, Vol 2, Iss 4, Pp 100208- (2022)

Abstract:Objective: To compare the rate of refractive growth (RRG3) of the crystalline lens (“lens”) versus the eye excluding the lens (“globe”) for the fellow, noncataractous eyes of participants in the Infant Aphakia Treatment Study. Design: Retrospective coh...

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Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma

Publication Type:Academic Journal

Source(s):The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)

Abstract:Cancers avoid immune surveillance through an array of mechanisms, including perturbation of HLA class I antigen presentation. Merkel cell carcinoma (MCC) is an aggressive, HLA-I–low, neuroendocrine carcinoma of the skin often caused by the Merkel cell ...

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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Publication Type:Periodical

Source(s):Nature Genetics; May 2022, Vol. 54 Issue: 5 p560-572, 13p

Abstract:We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic ass...

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Safety and immunogenicity of an HIV-1 prefusion-stabilized envelope trimer (Trimer 4571) vaccine in healthy adults: A first-in-human open-label, randomized, dose-escalation, phase 1 clinical trial

Publication Type:Academic Journal

Source(s):EClinicalMedicine, Vol 48, Iss , Pp 101477- (2022)

Abstract:Background: Advances in therapeutic drugs have increased life-expectancies for HIV-infected individuals, but the need for an effective vaccine remains. We assessed safety and immunogenicity of HIV-1 vaccine, Trimer 4571 (BG505 DS-SOSIP.664) adjuvanted ...

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Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Abstract:Penetrance of variants in monogenic disease and clinical utility of common polygenic variation has not been well explored on a large-scale. Here, the authors use exome sequencing data from 77,184 individuals to generate penetrance estimates and assess ...

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Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Abstract:Hydroxychloroquine and chloroquine have been investigated as a potential treatment for Covid-19 in several clinical trials. Here the authors report a meta-analysis of published and unpublished trials, and show that treatment with hydroxychloroquine for...

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Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7

Publication Type:Academic Journal

Source(s):Cell Reports, Vol 35, Iss 13, Pp 109292- (2021)

Abstract:Summary: We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding...

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Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study

Publication Type:Academic Journal

Source(s):The Lancet Public Health, Vol 6, Iss 5, Pp e335-e345 (2021)

Abstract:Summary: Background: The SARS-CoV-2 variant B.1.1.7 was first identified in December, 2020, in England. We aimed to investigate whether increases in the proportion of infections with this variant are associated with differences in symptoms or disease c...

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