scroll to top
0

Mobile Menu

Header Layout

EBSCO Auth Banner

Let's find your institution. Click here.

Page title

Advanced Search Results For "Chodera J"

1 - 10 of 116 results for
 "Chodera J"
Results per page:

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Abstract:The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.

View details

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

Publication Type:Academic Journal

Source(s):Cell Reports, Vol 29, Iss 1, Pp 62-75.e7 (2019)

Abstract:Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states. Id proteins are primarily expressed during development to inhi...

View details

The dynamic conformational landscape of the protein methyltransferase SETD8

Publication Type:Academic Journal

Source(s):eLife, Vol 8 (2019)

Abstract:Elucidating the conformational heterogeneity of proteins is essential for understanding protein function and developing exogenous ligands. With the rapid development of experimental and computational methods, it is of great interest to integrate these ...

View details

Ancestral reconstruction reveals mechanisms of ERK regulatory evolution

Publication Type:Academic Journal

Source(s):eLife, Vol 8 (2019)

Abstract:Protein kinases are crucial to coordinate cellular decisions and therefore their activities are strictly regulated. Previously we used ancestral reconstruction to determine how CMGC group kinase specificity evolved (Howard et al., 2014). In the present...

View details

Sharing Data from Molecular Simulations.

Publication Type:Academic Journal

Source(s):Journal of Chemical Information & Modeling; Oct2019, Vol. 59 Issue 10, p4093-4099, 7p

View details

Ensemble Docking in Drug Discovery

Publication Type:Periodical

Source(s):Biophysical Journal (Science Direct); May 2018, Vol. 114 Issue: 10 p2271-2278, 8p

Abstract:Ensemble docking corresponds to the generation of an “ensemble” of drug target conformations in computational structure-based drug discovery, often obtained by using molecular dynamics simulation, that is used in docking candidate ligands. This approac...

View details

OpenMM 4: A Reusable, Extensible, Hardware Independent Library for High Performance Molecular Simulation

Publication Type:Periodical

Source(s):Journal of Chemical Theory and Computation; January 2013, Vol. 9 Issue: 1 p461-469, 9p

Abstract:OpenMM is a software toolkit for performing molecular simulations on a range of high performance computing architectures. It is based on a layered architecture: the lower layers function as a reusable library that can be invoked by any application, whi...

View details

Limitations of Constant-Force-Feedback Experiments

Publication Type:Periodical

Source(s):Biophysical Journal (Science Direct); October 2012, Vol. 103 Issue: 7 p1490-1499, 10p

Abstract:Single-molecule force spectroscopy has provided important insights into the properties and mechanisms of biological molecules and systems. A common experiment is to measure the force dependence of conformational changes at equilibrium. Here, we demonst...

View details

Systematic Improvement of a Classical Molecular Modelof Water.

Publication Type:Academic Journal

Source(s):Journal of Physical Chemistry B; Aug2013, Vol. 117 Issue 34, p9956-9972, 17p

View details

banner_970x250 (970x250)

sponsored