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    • Impact of CTLA-4 checkpoint antibodies on ligand binding and Transendocytosis

    Publication Type: Academic Journal

    Source(s): Frontiers in Immunology, Vol 13 (2022)

    Abstract: Anti-CTLA-4 antibodies have pioneered the field of tumour immunotherapy. However, despite impressive clinical response data, the mechanism by which anti-CTLA-4 antibodies work is still controversial. Two major checkpoint antibodies (ipilimumab and trem...

    Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice

    Publication Type: Academic Journal

    Source(s): Frontiers in Aging Neuroscience, Vol 14 (2022)

    Abstract: Obesity is recognized as a significant risk factor for Alzheimer’s disease (AD). Studies have supported the notion that obesity accelerates AD-related pathophysiology in mouse models of AD. The majority of studies, to date, have focused on the use of e...

    Perinatal and 2-year neurodevelopmental outcome in late preterm fetal compromise: the TRUFFLE 2 randomised trial protocol

    Publication Type: Academic Journal

    Source(s): BMJ Open, Vol 12, Iss 4 (2022)

    Subjects:

    An in vivo platform to select and evolve aggregation-resistant proteins

    Publication Type: Academic Journal

    Source(s): Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

    Abstract: Protein aggregation remains a significant challenge for manufacturing of protein biopharmaceuticals. Here, the authors demonstrate the use of directed evolution and an assay for in vivo innate protein aggregation-propensity to generate aggregation-resi...

    Subjects:

    Qualitative Investigation into Therapists’ Experiences of Online Therapy: Implications for Working Clients

    Publication Type: Academic Journal

    Source(s): International Journal of Environmental Research and Public Health, Vol 18, Iss 10295, p 10295 (2021)

    Abstract: Online therapy has increasingly been utilised during the COVID-19 pandemic by many, including working populations. However, few qualitative studies have explored how online therapy is experienced in practice and discussed its implications for those wor...

    Challenges of Immune Response Diversity in the Human Population Concerning New Tuberculosis Diagnostics, Therapies, and Vaccines

    Publication Type: Academic Journal

    Source(s): Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)

    Abstract: Universal approaches to the prevention and treatment of human diseases fail to take into account profound immune diversity resulting from genetic variations across populations. Personalized or precision medicine takes into account individual lifestyle,...

    Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo

    Publication Type: Academic Journal

    Source(s): Neurobiology of Disease, Vol 132, Iss , Pp - (2019)

    Abstract: There are no approved drug therapies that can prevent or slow the progression of Parkinson's disease (PD). Accumulation and aggregation of α-synuclein protein is observed throughout the nervous system in PD. α-Synuclein is a core component of Lewy bodi...

    Comparing personal insight gains due to consideration of a recent dream and consideration of a recent event using the Ullman and Schredl dream group methods

    Publication Type: Academic Journal

    Source(s): Frontiers in Psychology, Vol 6 (2015)

    Abstract: There have been reports and claims in the psychotherapeutic literature that the consideration of recent dreams can result in personal realizations and insight. There is theoretical support for these claims from work on Rapid Eye Movement sleep having a...

    Indigenous Participation in Australian Economies II : Historical Engagements and Current Enterprises

    Indigenous Participation in Australian Economies II : Historical Engagements and Current Enterprises

    Publication Type: eBook

    Abstract: This is the second volume to emerge from a project on Indigenous participation in the Australian economy, funded by an Australian Research Council (ARC) Linkage Grant, and involving the cooperation of the School of Archaeology and Anthropology at The A...

    Teaching Palliative Care Skills Using Simulated Family Encounters

    Publication Type: Academic Journal

    Source(s): MedEdPORTAL, Vol 3 (2011)

    Abstract: Abstract While there has been a steady increase in awareness of end-of-life issues and palliative care for adults, there continues to be a shortfall in pediatric palliative care education, particularly for physicians in training. This resource is a cur...

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