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Advanced Search Results For "Clayton, Christopher"

1 - 10 of 2,230 results for
 "Clayton, Christopher"
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Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Abstract:Ancestry-related differences in immunobiology may explain the health disparities observed in prostate cancer patients, with men of African origin bearing the highest prostate cancer burden. By measuring immune-related proteins in serum samples, here th...

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Comparison of in silico strategies to prioritize rare genomic variants impacting RNA splicing for the diagnosis of genomic disorders

Publication Type:Academic Journal

Source(s):Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract:Abstract The development of computational methods to assess pathogenicity of pre-messenger RNA splicing variants is critical for diagnosis of human disease. We assessed the capability of eight algorithms, and a consensus approach, to prioritize 249 var...

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A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.

Publication Type:Academic Journal

Source(s):PLoS Biology, Vol 20, Iss 5, p e3001624 (2022)

Abstract:Test compounds used on in vitro model systems are conventionally delivered to cell culture wells as fixed concentration bolus doses; however, this poorly replicates the pharmacokinetic (PK) concentration changes seen in vivo and reduces the predictive ...

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High Seroprevalence of SARS-CoV-2 in White-Tailed Deer (Odocoileus virginianus) at One of Three Captive Cervid Facilities in Texas

Publication Type:Academic Journal

Source(s):Microbiology Spectrum, Vol 10, Iss 2 (2022)

Abstract:ABSTRACT Free-ranging white-tailed deer (Odocoileus virginianus) across the United States are increasingly recognized for infection and transmission of SARS-CoV-2. Through a cross-sectional study of 80 deer at three captive cervid facilities in central...

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Lipophilic vs. hydrophilic statins and psychiatric hospitalizations and emergency room visits in US Veterans with schizophrenia and bipolar disorder

Publication Type:Academic Journal

Source(s):Pteridines, Vol 32, Iss 1, Pp 48-69 (2021)

Abstract:Psychiatric hospitalizations and emergency department (ED) visits are costly, stigmatizing, and often ineffective. Given the immune and kynurenine activation in bipolar disorder (BD) and schizophrenia, as well as the immune-modulatory effects of statin...

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“A good death but there was all this tension around”- perspectives of residential managers on the experience of delivering end of life care for people living with dementia

Publication Type:Academic Journal

Source(s):BMC Geriatrics, Vol 21, Iss 1, Pp 1-9 (2021)

Abstract:Abstract Background End of life care for residents with advanced dementia in the aged care setting is complex. There is prolonged and progressive cognitive decline, uncertain disease trajectory, significant symptom burden and infrequent access to speci...

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Patient and public involvement prior to trial initiation: lessons learnt for rapid partnership in the COVID-19 era

Publication Type:Academic Journal

Source(s):Research Involvement and Engagement, Vol 7, Iss 1, Pp 1-7 (2021)

Abstract:Plain English summary Patient and Public Involvement (PPI) describes the active involvement of patients and the public in the research process. Through PPI, patients and members of the public are increasingly involved in the design and conduct of clini...

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Risky movements? Natal dispersal does not decrease survival of a large herbivore

Publication Type:Academic Journal

Source(s):Ecology and Evolution, Vol 11, Iss 6, Pp 2731-2740 (2021)

Abstract:Abstract Natal dispersal is assumed to be a particularly risky movement behavior as individuals transfer, often long distances, from birth site to site of potential first reproduction. Though, because this behavior persists in populations, it is assume...

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Reconfigurable all-dielectric metalens with diffraction-limited performance

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)

Abstract:Here, the authors report an active all-dielectric metasurface platform based on phase change materials, combining phase tuning in the full 2π range, and demonstrate aberration-free and multi-depth imaging with a non-mechanical tunable metalens.

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Time-Averaged Wavefront Analysis Demonstrates Preferential Pathways of Atrial Fibrillation, Predicting Pulmonary Vein Isolation Acute Response

Publication Type:Academic Journal

Source(s):Frontiers in Physiology, Vol 12 (2021)

Abstract:Electrical activation during atrial fibrillation (AF) appears chaotic and disorganised, which impedes characterisation of the underlying substrate and treatment planning. While globally chaotic, there may be local preferential activation pathways that ...

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