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Advanced Search Results For "Coles, P."

1 - 10 of 23,334 results for
 "Coles, P."
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Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Abstract: Cancers often harbor mutations in genes encoding important regulatory proteins, but therapeutic targeting of these molecules proves difficult due to their high structural similarity to their non-mutated counterpart. Here authors show the engineering of...

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De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a

Publication Type: Academic Journal

Source(s): Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-13 (2022)

Abstract: Abstract Epigenetic modifications to histone proteins serve an important role in regulating permissive and repressive chromatin states, but despite the identification of many histone PTMs and their perceived role, the epigenetic writers responsible for...

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Long-term declines in atmospheric nitrogen and sulfur deposition reduce critical loads exceedances at multiple Canadian rural sites, 2000–2018

Publication Type: Academic Journal

Source(s): Atmospheric Chemistry and Physics, Vol 22, Pp 14631-14656 (2022)

Abstract: Daily air concentrations of inorganic nitrogen (N) species, including gaseous HNO3 and particulate-bound (p)NH4+ and pNO3-, and sulfur (S) species, including SO2 and pSO42-, and precipitation concentrations of NO3-, NH4+, and SO42-, have been routinely...

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Measurement of the polarisation of single top quarks and antiquarks produced in the t-channel at s $$ \sqrt{s} $$ = 13 TeV and bounds on the tWb dipole operator from the ATLAS experiment

Publication Type: Academic Journal

Source(s): Journal of High Energy Physics, Vol 2022, Iss 11, Pp 1-62 (2022)

Abstract: Abstract A simultaneous measurement of the three components of the top-quark and top-antiquark polarisation vectors in t-channel single-top-quark production is presented. This analysis is based on data from proton–proton collisions at a centre-of-mass ...

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The diagnostic and prognostic potential of the EGFR/MUC4/MMP9 axis in glioma patients

Publication Type: Academic Journal

Source(s): Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract: Abstract Glioblastoma is the most aggressive form of brain cancer, presenting poor prognosis despite current advances in treatment. There is therefore an urgent need for novel biomarkers and therapeutic targets. Interactions between mucin 4 (MUC4) and ...

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A glutamine-based single α-helix scaffold to target globular proteins

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Abstract: Targeting biomedically relevant protein-protein interactions is a long-lasting challenge in medicinal chemistry. Here, the authors develop a single α-helical peptide scaffold that can be tailored to target globular proteins of biomedical interest.

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Long-time simulations for fixed input states on quantum hardware

Publication Type: Academic Journal

Source(s): npj Quantum Information, Vol 8, Iss 1, Pp 1-12 (2022)

Abstract: Abstract Publicly accessible quantum computers open the exciting possibility of experimental dynamical quantum simulations. While rapidly improving, current devices have short coherence times, restricting the viable circuit depth. Despite these limitat...

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Cross-Sectional Brain-Predicted Age Differences in Community-Dwelling Middle-Aged and Older Adults with High Impact Knee Pain

Publication Type: Academic Journal

Source(s): Journal of Pain Research, Vol Volume 15, Pp 3575-3587 (2022)

Abstract: Alisa J Johnson,1,2,* Taylor Buchanan,3,* Chavier Laffitte Nodarse,1,2 Pedro A Valdes Hernandez,1,2 Zhiguang Huo,4 James H Cole,5,6 Thomas W Buford,3 Roger B Fillingim,1,2,7 Yenisel Cruz-Almeida1,2,7 1Pain Research & Intervention Center of Exce...

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Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-29 (2022)

Abstract: Lifespan can be affected by both physiological ageing and specific sets of pathologies associated with old age. Here the authors report a resource of large-scale cross-sectional phenotyping of aging male mice at different time points to analyse a large...

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Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Abstract: Skeletal progenitors provide a reservoir for bone-forming osteoblasts. However, the major energy source for their osteogenesis remains unresolved. Here, the authors demonstrate that ESCIT-mediated regulation of mitochondrial metabolism is required for ...

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