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ePHex: a phase 3, double-blind, placebo-controlled, randomized study to evaluate long-term efficacy and safety of Oxalobacter formigenes in patients with primary hyperoxaluria.
Publication Type: Academic Journal
Source(s): Pediatric Nephrology; Feb2023, Vol. 38 Issue 2, p403-415, 13p, 1 Diagram, 4 Charts, 3 Graphs
Abstract: Copyright of Pediatric Nephrology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, o...
- KIDNEY physiology
- DRUG efficacy
- GLOMERULAR filtration rate
- CONFIDENCE intervals
- ORAL drug administration
- GRAM-negative anaerobic bacteria
- KIDNEY diseases
- RANDOMIZED controlled trials
- INBORN errors of carbohydrate metabolism
- BLIND experiment
- DESCRIPTIVE statistics
- PHARMACEUTICAL chemistry
- OXALIC acid
- STATISTICAL sampling
- PATIENT safety
- EVALUATION
Effects of Oxalobacter formigenes in subjects with primary hyperoxaluria Type 1 and end-stage renal disease: a Phase II study.
Publication Type: Academic Journal
Source(s): Nephrology Dialysis Transplantation; Aug2021, Vol. 36 Issue 8, p1464-1473, 10p
Abstract: Copyright of Nephrology Dialysis Transplantation is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However,...
Plasma oxalate and eGFR are correlated in primary hyperoxaluria patients with maintained kidney function—data from three placebo-controlled studies.
Publication Type: Academic Journal
Source(s): Pediatric Nephrology; Jul2021, Vol. 36 Issue 7, p1785-1793, 9p, 2 Charts, 2 Graphs
Abstract: Copyright of Pediatric Nephrology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, o...
Is serum phosphorus control related to parathyroid hormone control in dialysis patients with secondary hyperparathyroidism?
Publication Type: Academic Journal
Source(s): BMC Nephrology, Vol 13, Iss 1, p 76 (2012)
Abstract: Abstract Background Elevated serum phosphorus (P) levels have been linked to increased morbidity and mortality in dialysis patients with secondary hyperparathyroidism (SHPT) but may be difficult to control if parathyroid hormone (PTH) is persistently e...
Low Energy Electron Irradiation Is a Potent Alternative to Gamma Irradiation for the Inactivation of (CAR-)NK-92 Cells in ATMP Manufacturing
Publication Type: Academic Journal
Source(s): Frontiers in Immunology, Vol 12 (2021)
Abstract: BackgroundWith increasing clinical use of NK-92 cells and their CAR-modified derivatives in cancer immunotherapy, there is a growing demand for efficient production processes of these “off-the-shelf” therapeutics. In order to ensure safety and prevent ...
Natural History of Clinical, Laboratory, and Echocardiographic Parameters of a Primary Hyperoxaluria Cohort on Long Term Hemodialysis
Publication Type: Academic Journal
Source(s): Frontiers in Medicine, Vol 8 (2021)
Abstract: Background: Primary hyperoxaluria type 1 (PH1) is a rare monogenic disorder characterized by excessive hepatic production of oxalate leading to recurrent nephrolithiasis, nephrocalcinosis, and progressive kidney damage, often requiring renal replacemen...
A randomized, double-blind, placebo-controlled study to assess the efficacy and safety of cinacalcet in pediatric patients with chronic kidney disease and secondary hyperparathyroidism receiving dialysis.
Publication Type: Academic Journal
Source(s): Pediatric Nephrology; Mar2019, Vol. 34 Issue 3, p475-486, 12p, 1 Diagram, 5 Charts, 2 Graphs
Abstract: Copyright of Pediatric Nephrology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, o...
- TREATMENT of chronic kidney failure
- CALCIUM
- CALCIUM-binding proteins
- CONFIDENCE intervals
- DRUG side effects
- HEMODIALYSIS
- HYPERPARATHYROIDISM
- HYPERTENSION
- HYPOCALCEMIA
- PARATHYROID hormone
- PEDIATRICS
- PHOSPHORUS
- TERMINATION of treatment
- RANDOMIZED controlled trials
- TREATMENT effectiveness
- BLIND experiment
- THERAPEUTICS
An open-label, single-dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of cinacalcet in pediatric subjects aged 28 days to
Publication Type: Academic Journal
Source(s): Pediatric Nephrology; Jan2019, Vol. 34 Issue 1, p145-154, 10p, 1 Diagram, 3 Charts, 6 Graphs
Abstract: The article presents a study evaluating the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of cinacalcet in children with chronic kidney disease (CKD) and secondary hyperparathyroidism (SHPT). It concludes that a single dose of ...
A Decision-Analytic Model to Assess the Cost-Effectiveness of Etelcalcetide vs. Cinacalcet.
Publication Type: Academic Journal
Source(s): PharmacoEconomics; May2018, Vol. 36 Issue 5, p603-612, 10p
Abstract: Copyright of PharmacoEconomics is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or e...
Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial.
Publication Type: Academic Journal
Source(s): JAMA: Journal of the American Medical Association; 1/10/2017, Vol. 317 Issue 2, p156-164, 9p, 1 Diagram, 2 Charts, 2 Graphs
Abstract: Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permiss...
- PEPTIDOMIMETICS
- HYPERTHYROIDISM treatment
- CALCIUM in the body
- PARATHYROID hormone
- BLOOD serum analysis
- HEMODIALYSIS patients
- CALCIUM-sensing receptors
- GRAFT versus host disease
- MEDICAL care
- THERAPEUTICS
- TREATMENT of chronic kidney failure
- CHRONIC kidney failure complications
- CALCIUM
- COMPARATIVE studies
- GROWTH factors
- HEMODIALYSIS
- HORMONE antagonists
- HYPERPARATHYROIDISM
- INTRAVENOUS therapy
- RESEARCH methodology
- MEDICAL cooperation
- NAUSEA
- ORAL drug administration
- PEPTIDES
- RESEARCH
- TIME
- VOMITING
- EVALUATION research
- RANDOMIZED controlled trials
- BLIND experiment