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Advanced Search Results For "Douglas, Paul H."

1 - 10 of 4,169 results for
 "Douglas, Paul H."
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Electron microscopy of antibody-conjugated, lutetium-177 lanthanide gold-coated nanoparticles: Proof of concept of targeted loci—A potential theranostic agent

Publication Type: Academic Journal

Source(s): AIP Advances, Vol 11, Iss 4, Pp 045035-045035-8 (2021)

Abstract: Following murine injection, the ultrastructural loci of nanoparticles (NPs) containing lutetium-177 (Lu-177) conjugated to an anti-thrombomodulin antibody (mAb-201b) were determined. The results confirmed prior work localizing NPs using Single Photon E...

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Sham-Controlled Study of Optokinetic Stimuli as Treatment for Mal de Debarquement Syndrome

Publication Type: Academic Journal

Source(s): Frontiers in Neurology, Vol 9 (2018)

Abstract: Introduction: Mal de Debarquement Syndrome (MdDS) is a condition characterized by a perception of self-motion in the absence of a stimulus, with two onset types: Motion-Triggered and Spontaneous. Currently, the pathophysiology is unknown and consequent...

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The Fecal Microbiota in the Domestic Cat (Felis catus) Is Influenced by Interactions Between Age and Diet; A Five Year Longitudinal Study

Publication Type: Academic Journal

Source(s): Frontiers in Microbiology, Vol 9 (2018)

Abstract: In humans, aging is associated with changes in the gastrointestinal microbiota; these changes may contribute to the age-related increase in incidence of many chronic diseases, including Type 2 diabetes. The life expectancies of cats are increasing, and...

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A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol

Publication Type: Academic Journal

Source(s): Journal of Lipid Research, Vol 56, Iss 12, Pp 2408-2419 (2015)

Abstract: Cholesterol homeostasis is regulated not only by cholesterol, but also by oxygenated cholesterol species, referred to as oxysterols. Side-chain oxysterols, such as 25-hydroxycholesterol (25-HC), regulate cholesterol homeostasis through feedback inhibit...

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Evaluation of approaches to monitor Staphylococcus aureus virulence factor expression during human disease.

Publication Type: Academic Journal

Source(s): PLoS ONE, Vol 10, Iss 2, p e0116945 (2015)

Abstract: Staphylococcus aureus is a versatile pathogen of medical significance, using multiple virulence factors to cause disease. A prophylactic S. aureus 4-antigen (SA4Ag) vaccine comprising capsular polysaccharide (types 5 and 8) conjugates, clumping factor ...

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Minimally invasive method for murine brain fixation

Publication Type: Academic Journal

Source(s): BioTechniques, Vol 39, Iss 4, Pp 487-490 (2005)

Abstract: Complete brain fixation can be achieved with transthoracic cardiac infusion without thoracotomy. Light and electron microscopy tissue sections reveal preservation of cytoplasmic and nuclear structure at all magnification levels. Punched samples were ob...

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Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers

Publication Type: Academic Journal

Source(s): Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)

Abstract: The risk of germline copy number variants (CNVs) in BRCA1 and BRCA2 pathogenic variant carriers in breast cancer is assessed, with CNVs overlapping SULT1A1 decreasing breast cancer risk in BRCA1 carriers.

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Genomic insights into rapid speciation within the world’s largest tree genus Syzygium

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Abstract: The relative importance of the mechanisms underlying species radiation remains unclear. Here, the authors combine reference genome assembly and population genetics analyses to show that neutral forces have contributed to the radiation of the most speci...

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Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort studyResearch in context

Publication Type: Academic Journal

Source(s): EClinicalMedicine, Vol 55, Iss , Pp 101724- (2023)

Abstract: Summary: Background: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking. Methods: A retrospective multi-centr...

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PredictCBC-2.0: a contralateral breast cancer risk prediction model developed and validated in ~ 200,000 patients

Publication Type: Academic Journal

Source(s): Breast Cancer Research, Vol 24, Iss 1, Pp 1-14 (2022)

Abstract: Abstract Background Prediction of contralateral breast cancer (CBC) risk is challenging due to moderate performances of the known risk factors. We aimed to improve our previous risk prediction model (PredictCBC) by updated follow-up and including addit...

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