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Advanced Search Results For "Dresser R"

1 - 10 of 558 results for
 "Dresser R"
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Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Abstract:Targeting genotype-independent abnormalities may overcome therapy resistance in glioblastoma despite intratumoral genomic heterogeneity. Here, the authors show that glioblastoma radiation resistance is promoted by purine metabolism and can be overcome ...

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Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy

Publication Type:Academic Journal

Source(s):Cancer & Metabolism, Vol 8, Iss 1, Pp 1-16 (2020)

Abstract:Abstract Background Metabolic programs in cancer cells are influenced by genotype and the tissue of origin. We have previously shown that central carbon metabolism is rewired in pancreatic ductal adenocarcinoma (PDA) to support proliferation through a ...

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Telomere-led meiotic chromosome movements: recent update in structure and function

Publication Type:Academic Journal

Source(s):Nucleus, Vol 11, Iss 1, Pp 111-116 (2020)

Abstract:In S. cerevisiae prophase meiotic chromosomes move by forces generated in the cytoplasm and transduced to the telomere via a protein complex located in the nuclear membrane. We know that chromosome movements require actin cytoskeleton [13,31] and the p...

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HrpA, a DEAH-box RNA helicase, is involved in global gene regulation in the Lyme disease spirochete.

Publication Type:Academic Journal

Source(s):PLoS ONE, Vol 6, Iss 7, p e22168 (2011)

Abstract:Spirochetes causing Lyme borreliosis are obligate parasites that can only be found in a tick vector or a vertebrate host. The ability to survive in these two disparate environments requires up and downregulation of specific genes by regulatory circuits...

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PUMA: An Operating System for Massively Parallel Systems

Publication Type:Academic Journal

Source(s):Scientific Programming, Vol 3, Iss 4, Pp 275-288 (1994)

Abstract:This article presents an overview of PUMA (Performance-oriented, User-managed Messaging Architecture), a message-passing kernel for massively parallel systems. Message passing in PUMA is based on portals – an opening in the address space of an applicat...

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Investigation of the genes involved in antigenic switching at the vlsE locus in Borrelia burgdorferi: an essential role for the RuvAB branch migrase.

Publication Type:Academic Journal

Source(s):PLoS Pathogens, Vol 5, Iss 12, p e1000680 (2009)

Abstract:Persistent infection by pathogenic organisms requires effective strategies for the defense of these organisms against the host immune response. A common strategy employed by many pathogens to escape immune recognition and clearance is to continually va...

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Molecular mechanisms involved in vascular interactions of the Lyme disease pathogen in a living host.

Publication Type:Academic Journal

Source(s):PLoS Pathogens, Vol 4, Iss 10, p e1000169 (2008)

Abstract:Hematogenous dissemination is important for infection by many bacterial pathogens, but is poorly understood because of the inability to directly observe this process in living hosts at the single cell level. All disseminating pathogens must tether to t...

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Preferences for return of incidental findings from genome sequencing among women diagnosed with breast cancer at a young age.

Publication Type:Academic Journal

Source(s):Clinical Genetics; Mar2016, Vol. 89 Issue 3, p378-384, 7p

Abstract:Copyright of Clinical Genetics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or e...

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Research subjects' voices: the missing element in research ethics.

Publication Type:Academic Journal

Source(s):Anaesthesia & Intensive Care; 2015, Vol. 43 Issue 3, p297-299, 3p

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Protection of human subjects and scientific progress: can the two be reconciled?

Publication Type:Academic Journal

Source(s):Hastings Center Report; Jan/Feb2006, Vol. 36 Issue 1, p4-9, 6p

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