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Clearance of defective muscle stem cells by senolytics restores myogenesis in myotonic dystrophy type 1
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract: Abstract Muscle stem cells, the engine of muscle repair, are affected in myotonic dystrophy type 1 (DM1); however, the underlying molecular mechanism and the impact on the disease severity are still elusive. Here, we show using patients’ samples that m...
Characterization of the genetic pool of the Canadienne dairy cattle breed
Publication Type: Academic Journal
Source(s): Genetics Selection Evolution, Vol 55, Iss 1, Pp 1-11 (2023)
Abstract: Abstract Background Canadienne cattle are the oldest breed of dairy cattle in North America. The Canadienne breed originates from cattle that were brought to America by the mid-seventeenth century French settlers. The herd book was established in 1886 ...
A rehabilitation program to increase balance and mobility in ataxia of Charlevoix-Saguenay: An exploratory study
Publication Type: Academic Journal
Source(s): PLoS ONE, Vol 17, Iss 12 (2022)
Abstract: Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is characterized by balance impairment and mobility limitations, which both increase the risk of falling. The objective of this study was to explore the effects of a rehabilitation prog...
Exposure to ambient air pollution and cognitive decline: Results of the prospective Three-City cohort study
Publication Type: Academic Journal
Source(s): Environment International, Vol 161, Iss , Pp 107118- (2022)
Abstract: Background: Growing epidemiological evidence suggests an adverse relationship between exposure to air pollutants and cognitive decline. However, there is still some heterogeneity in the findings, with inconsistent results depending on the pollutant and...
Annual aboveground carbon uptake enhancements from assisted gene flow in boreal black spruce forests are not long-lasting
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Abstract: The long-term effectiveness of assisted gene flow of trees could be jeopardised by rapid climate change. Here the authors analyse a large dataset of relocated black spruce populations in Canada, finding that local adaptation to climate of origin improv...
Acti-DM1: Monitoring the Activity Level of People With Myotonic Dystrophy Type 1 Through Activity and Exercise Recognition
Publication Type: Academic Journal
Source(s): IEEE Access, Vol 9, Pp 49960-49973 (2021)
Abstract: Myotonic dystrophy type 1 (DM1) is a rare disease where the highest prevalence is found in the small geographical region of Saguenay-Lac-St-Jean in Quebec, Canada. This disease impacts the quality of life and the ability of the affected people to pursu...
A practical study of CITES wood species identification by untargeted DART/QTOF, GC/QTOF and LC/QTOF together with machine learning processes and statistical analysis
Publication Type: Academic Journal
Source(s): Environmental Advances, Vol 5, Iss , Pp 100089- (2021)
Abstract: Illegal logging and trafficking of endangered timber species has attracted the world's major organized crime groups, with associated deforestation and serious social damage. The inability of traditional methodologies and DNA analysis to readily perform...
A dataset of long-term consistency values of resting-state fMRI connectivity maps in a single individual derived at multiple sites and vendors using the Canadian Dementia Imaging Protocol
Publication Type: Academic Journal
Source(s): Data in Brief, Vol 31, Iss , Pp 105699- (2020)
Abstract: The impact of multisite acquisition on resting-state functional MRI (rsfMRI) connectivity has recently gained attention. We provide consistency values (Pearson's correlation) between rsfMRI connectivity maps of an adult volunteer (Csub) scanned 25 time...
Using X-ray CT Scanned Reconstructed Logs to Predict Knot Characteristics and Tree Value
Publication Type: Academic Journal
Source(s): Forests, Vol 12, Iss 720, p 720 (2021)
Abstract: Research Highlights: Stand density was connected with wood quality and lumber production to develop a predictive model to better estimate tree value. Background and Objectives: The available standing wood volume in British Columbia (BC), Canada has con...
Effects of concentrated long-chain omega-3 polyunsaturated fatty acid supplementation before radical prostatectomy on prostate cancer proliferation, inflammation, and quality of life: study protocol for a phase IIb, randomized, double-blind, placebo-controlled trial
Publication Type: Academic Journal
Source(s): BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract: Abstract Background Prostate cancer is the most commonly diagnosed cancer in north-American men. Few dietary or lifestyle interventions have been tested to prevent prostate cancer progression. Omega-3 fatty acid supplementation represents a promising i...