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Quantitative Assessment and Comparative Analysis of Longitudinal Lung CT Scans of Chest-Irradiated Nonhuman Primates.
Publication Type: Academic Journal
Source(s): Radiation research [Radiat Res] 2023 Jan 01; Vol. 199 (1), pp. 39-47.
Abstract: Computed tomography (CT) imaging has been used to diagnose radiation-induced lung injury for decades. However, histogram-based quantitative tools have rarely been applied to assess lung abnormality due to radiation-induced lung injury (RILI). Here, we ...
Leveraging International Influenza Surveillance Systems and Programs during the COVID-19 Pandemic.
Publication Type: Academic Journal
Source(s): Emerging infectious diseases [Emerg Infect Dis] 2022 Dec; Vol. 28 (13), pp. S26-S33.
Abstract: A network of global respiratory disease surveillance systems and partnerships has been built over decades as a direct response to the persistent threat of seasonal, zoonotic, and pandemic influenza. These efforts have been spearheaded by the World Heal...
Total-Body Irradiation Is Associated With Increased Incidence of Mesenchymal Neoplasia in a Radiation Late Effects Cohort of Rhesus Macaques (Macaca mulatta).
Publication Type: Academic Journal
Source(s): International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2022 Jul 01; Vol. 113 (3), pp. 661-674. Date of Electronic Publication: 2022 Mar 29.
Abstract: Purpose: Cancer is a severe delayed effect of acute radiation exposure. Total-body irradiation has been associated with an increased risk of solid cancer and leukemia in Japanese atomic bomb survivors, and secondary malignancies, such as sarcoma, are a...
Age effects on radiation response: summary of a recent symposium and future perspectives.
Publication Type: Academic Journal
Source(s): International journal of radiation biology [Int J Radiat Biol] 2022 May 02, pp. 1-11. Date of Electronic Publication: 2022 May 02.
Abstract: One of the principal uncertainties when estimating population risk of late effects from epidemiological data is that few radiation-exposed cohorts have been followed up to extinction. Therefore, the relative risk model has often been used to estimate r...
Hypertension promotes microbial translocation and dysbiotic shifts in the fecal microbiome of nonhuman primates.
Publication Type: Academic Journal
Source(s): American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2022 Mar 01; Vol. 322 (3), pp. H474-H485. Date of Electronic Publication: 2022 Feb 11.
Abstract: Accumulating evidence indicates a link between gut barrier dysfunction and hypertension. However, it is unclear whether hypertension causes gut barrier dysfunction or vice versa and whether the gut microbiome plays a role. To understand this relationsh...
Predicting mortality in nonsurgical patients before cannulation for veno-arterial extracorporeal life support: Development and validation of the LACT-8 score.
Publication Type: Academic Journal
Source(s): Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions [Catheter Cardiovasc Interv] 2022 Mar; Vol. 99 (4), pp. 1115-1124. Date of Electronic Publication: 2022 Feb 03.
Abstract: Objectives: We sought to derive and validate a model to predict inpatient mortality after veno-arterial extracorporeal life support (VA-ECLS) based on readily available, precannulation clinical data.Background: Refractory cardiogenic shock supported by...
Clinicopathologic and Transcriptomic Analysis of Radiation-Induced Lung Injury in Nonhuman Primates.
Publication Type: Academic Journal
Source(s): International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2021 Sep 01; Vol. 111 (1), pp. 249-259. Date of Electronic Publication: 2021 Apr 20.
Abstract: Purpose: Radiation-induced lung injury (RILI) is a progressive condition with an early phase (radiation pneumonitis) and a late phase (lung fibrosis). RILI may occur after partial-body ionizing radiation exposures or internal radioisotope exposure, wit...
Non-Human Primates Receiving High-Dose Total-Body Irradiation are at Risk of Developing Cerebrovascular Injury Years Postirradiation.
Publication Type: Academic Journal
Source(s): Radiation research [Radiat Res] 2020 Sep 16; Vol. 194 (3), pp. 277-287.
Abstract: Nuclear accidents and acts of terrorism have the potential to expose thousands of people to high-dose total-body iradiation (TBI). Those who survive the acute radiation syndrome are at risk of developing chronic, degenerative radiation-induced injuries...
Detection and quantification of renal fibrosis by computerized tomography.
Publication Type: Academic Journal
Source(s): PloS one [PLoS One] 2020 Feb 13; Vol. 15 (2), pp. e0228626. Date of Electronic Publication: 2020 Feb 13 (Print Publication: 2020).
Abstract: Objectives: Reliable biomarkers for renal fibrosis are needed for clinical care and for research. Existing non-invasive biomarkers are imprecise, which has limited their utility.Methods: We developed a method to quantify fibrosis by subject size-adjust...
Monocyte Polarization is Altered by Total-Body Irradiation in Male Rhesus Macaques: Implications for Delayed Effects of Acute Radiation Exposure.
Publication Type: Academic Journal
Source(s): Radiation research [Radiat Res] 2019 Aug; Vol. 192 (2), pp. 121-134. Date of Electronic Publication: 2019 Jun 04.
Abstract: Radiation-induced fibrosis (RIF) is a common delayed effect of acute ionizing radiation exposure (DEARE) affecting diverse tissues including the heart, lungs, liver and skin, leading to reduced tissue function and increased morbidity. Monocytes, which ...