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Evaluation of levocetirizine in beagle dog and cynomolgus monkey telemetry assays: Defining the no QTc effect profile by timepoint and concentration‐QTc analysis
Publication Type: Academic Journal
Source(s): Clinical and Translational Science, Vol 16, Iss 3, Pp 436-446 (2023)
Abstract: Abstract In prior clinical studies, levocetirizine (LEVO) has demonstrated no effect on ventricular repolarization (QTc intervals), therefore it is a relevant negative control to assess in nonclinical assays to define low proarrhythmic risk. LEVO was t...
Present and future challenges for the investigation of transgenerational epigenetic inheritance
Publication Type: Academic Journal
Source(s): Environment International, Vol 172, Iss , Pp 107776- (2023)
Abstract: Epigenetic pathways are essential in different biological processes and in phenotype-environment interactions in response to different stressors and they can induce phenotypic plasticity. They encompass several processes that are mitotically and, in so...
Socio-cultural perception of robot backchannels
Publication Type: Academic Journal
Source(s): Frontiers in Robotics and AI, Vol 10 (2023)
Abstract: Introduction: Backchannels, i.e., short interjections by an interlocutor to indicate attention, understanding or agreement regarding utterances by another conversation participant, are fundamental in human-human interaction. Lack of backchannels or if ...
A Novel Nanosafety Approach Using Cell Painting, Metabolomics, and Lipidomics Captures the Cellular and Molecular Phenotypes Induced by the Unintentionally Formed Metal-Based (Nano)Particles
Publication Type: Academic Journal
Source(s): Cells, Vol 12, Iss 281, p 281 (2023)
Abstract: Additive manufacturing (AM) or industrial 3D printing uses cutting-edge technologies and materials to produce a variety of complex products. However, the effects of the unintentionally emitted AM (nano)particles (AMPs) on human cells following inhalati...
Recovering from COVID-19 – A Process Characterised by Uncertainty: A Qualitative study
Publication Type: Academic Journal
Source(s): Journal of Rehabilitation Medicine, Vol 54 (2022)
Abstract: Objective: To obtain a deeper understanding of the lived experiences of patients with COVID-19, the recovery process and consequences for everyday life 6 months after hospital discharge. Design: An explorative qualitative study using individual intervi...
Back to life: Is it possible to be myself again? A qualitative study with persons initially hospitalised due to COVID-19
Publication Type: Academic Journal
Source(s): Journal of Rehabilitation Medicine, Vol 54 (2022)
Abstract: Objective: To gain a deeper understanding of the lived experiences of patients with COVID-19, regarding rehabilitation, work and social life 6 months after hospital discharge. Design: An explorative qualitative study with individual interviews. Subject...
Comprehensive Review of Reported Nonclassical Spindle Cell Lipoma Presentations and a Unique Case Report
Publication Type: Academic Journal
Source(s): Plastic and Reconstructive Surgery, Global Open, Vol 10, Iss 8, p e4462 (2022)
Abstract: Introduction:. Spindle cell lipoma (SCL) is a rare subset of benign lipomatous neoplasms, making up approximately 1.5% of all adipocytic neoplasms. Since SCLs were first described in 1975, numerous nonclassical cases have been reported in the literatur...
Evaluation of moxifloxacin in canine and non‐human primate telemetry assays: Comparison of QTc interval prolongation by timepoint and concentration‐QTc analysis
Publication Type: Academic Journal
Source(s): Clinical and Translational Science, Vol 14, Iss 6, Pp 2379-2390 (2021)
Abstract: Abstract The in vivo correct QT (QTc) assay is used by the pharmaceutical industry to characterize the potential for delayed ventricular repolarization and is a core safety assay mentioned in International Conference on Harmonization (ICH) S7B guidelin...
Particle Safety Assessment in Additive Manufacturing: From Exposure Risks to Advanced Toxicology Testing
Publication Type: Academic Journal
Source(s): Frontiers in Toxicology, Vol 4 (2022)
Abstract: Additive manufacturing (AM) or industrial three-dimensional (3D) printing drives a new spectrum of design and production possibilities; pushing the boundaries both in the application by production of sophisticated products as well as the development of...
Tantalum Suboxide Films with Tunable Composition and Electrical Resistivity Deposited by Reactive Magnetron Sputtering
Publication Type: Academic Journal
Source(s): Coatings, Vol 12, Iss 917, p 917 (2022)
Abstract: Tantalum-based films with tailored composition, density, and electrical resistivity are of interest for next generation hohlraums for magnetized indirect-drive inertial confinement fusion. Here, we use reactive direct-current magnetron sputtering to de...