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Advanced Search Results For "FOSTER, DANIEL"

1 - 10 of 3,692 results for
 "FOSTER, DANIEL"
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Rencofilstat, a cyclophilin inhibitor: A phase 2a, multicenter, single‐blind, placebo‐controlled study in F2/F3 NASH

Publication Type: Academic Journal

Source(s): Hepatology Communications, Vol 6, Iss 12, Pp 3379-3392 (2022)

Abstract: Abstract Rencofilstat (RCF) demonstrated antifibrotic effects in preclinical models and was safe and well tolerated in Phase 1 studies. The aim of this Phase 2a study was safety, tolerability, pharmacokinetics, and exploration of efficacy biomarkers in...

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Tibial Baseplate-Cement Interface Debonding in the ATTUNE Total Knee Arthroplasty System

Publication Type: Academic Journal

Source(s): Arthroplasty Today, Vol 17, Iss , Pp 165-171 (2022)

Abstract: Background: Acrylic bone cement is the most common method of fixation for primary total knee arthroplasty (TKA). Several studies have described good short-term outcomes; however, there have been reports of early failures due to tibial baseplate debondi...

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The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates

Publication Type: Academic Journal

Source(s): Molecular Cancer, Vol 21, Iss 1, Pp 1-16 (2022)

Abstract: Abstract Background Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development. In the present study we applied Who...

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SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern

Publication Type: Academic Journal

Source(s): EBioMedicine, Vol 84, Iss , Pp 104270- (2022)

Abstract: Summary: Background: Genetically distinct viral variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been recorded since January 2020. The introduction of global vaccine programs has contributed to lower COVID-19 hospitalisatio...

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RNase III CLASH in MRSA uncovers sRNA regulatory networks coupling metabolism to toxin expression

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Abstract: Regulatory small RNA (sRNA) interact with mRNAs to regulate their stability, transcription, and translation via diverse mechanisms. Here, McKellar et al. apply RNase IIICLASH of multi-drug resistant Staphylococcus aureus under different culture conditi...

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Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Publication Type: Academic Journal

Source(s): The Lancet Global Health, Vol 10, Iss 7, Pp e1003-e1011 (2022)

Abstract: Summary: Background: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of ...

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Distinct population and single-neuron selectivity for executive and episodic processing in human dorsal posterior cingulate

Publication Type: Academic Journal

Source(s): eLife, Vol 11 (2022)

Abstract: Posterior cingulate cortex (PCC) is an enigmatic region implicated in psychiatric and neurological disease, yet its role in cognition remains unclear. Human studies link PCC to episodic memory and default mode network (DMN), while findings from the non...

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Cannabinoid type-2 receptors: An emerging target for regulating schizophrenia-relevant brain circuits

Publication Type: Academic Journal

Source(s): Frontiers in Neuroscience, Vol 16 (2022)

Abstract: Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune system, emerging evidence points to CB2 playing a key role in regulating neuronal function in the central nervous system. Recent anatomical studies, combined with electrop...

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Ebola Virus Glycoprotein IgG Seroprevalence in Community Previously Affected by Ebola, Sierra Leone

Publication Type: Academic Journal

Source(s): Emerging Infectious Diseases, Vol 28, Iss 3, Pp 734-738 (2022)

Abstract: We explored the association of Ebola virus antibody seropositivity and concentration with potential risk factors for infection. Among 1,282 adults and children from a community affected by the 2014–2016 Ebola outbreak in Sierra Leone, 8% were seroposit...

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'In vitro' assessments of microencapsulated viable cells as a result of primary bile acid-encapsulated formulation for inflammatory disorders

Publication Type: Academic Journal

Source(s): Scripta Medica, Vol 53, Iss 2, Pp 103-115 (2022)

Abstract: Background / Aim: Metformin is widely used in type 2 diabetes and exhibits many positive biological effects on pancreatic b-cells and muscle cells, such as supporting insulin release by b-cells and glucose uptake by muscle cells and reducing oxidative ...

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