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The precision medicine process for treating rare disease using the artificial intelligence tool mediKanren
Publication Type: Academic Journal
Source(s): Frontiers in Artificial Intelligence, Vol 5 (2022)
Abstract: There are over 6,000 different rare diseases estimated to impact 300 million people worldwide. As genetic testing becomes more common practice in the clinical setting, the number of rare disease diagnoses will continue to increase, resulting in the nee...
Ramelteon for Insomnia Related to Attention-Deficit/Hyperactivity Disorder (ADHD).
Publication Type: Academic Journal
Source(s): Psychopharmacology Bulletin; 2011, Vol. 44 Issue 2, p32-53, 22p, 5 Charts, 2 Graphs
The response properties of retinula cells in the flyCalliphora erythrocephala as a function of the wavelength and polarization properties of visible and ultraviolet light
Publication Type: Periodical
Source(s): Biological Cybernetics; June 1977, Vol. 26 Issue: 2 p93-107, 15p
Abstract: Detailed functional response properties of the class (1–6) retinula cells in the insectCalliphora erythrocephela have been determined as a function of the wavelength of monochromatic light and polarization conditions over a six log unit range of light ...
Unearthing SRSF1's Novel Function in Binding and Unfolding of RNA G-Quadruplexes.
Source(s): BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 02. Date of Electronic Publication: 2023 Nov 02.
Abstract: SRSF1 governs splicing of over 1,500 mRNA transcripts. SRSF1 contains two RNA-recognition motifs (RRMs) and a C-terminal Arg/Ser-rich region (RS). It has been thought that SRSF1 RRMs exclusively recognize single-stranded exonic splicing enhancers, whil...
Electronegative clusters modulate folding status and RNA binding of unstructured RNA-binding proteins.
Publication Type: Academic Journal
Source(s): Protein science : a publication of the Protein Society [Protein Sci] 2023 May; Vol. 32 (5), pp. e4643.
Abstract: Electronegative clusters (ENCs) made up of acidic residues and/or phosphorylation sites are the most abundant repetitive sequences in RNA-binding proteins. Previous studies have indicated that ENCs inhibit RNA binding for structured RNA-binding domains...
Peptides that Mimic RS repeats modulate phase separation of SRSF1, revealing a reliance on combined stacking and electrostatic interactions.
Publication Type: Academic Journal
Source(s): ELife [Elife] 2023 Mar 02; Vol. 12. Date of Electronic Publication: 2023 Mar 02.
Abstract: Phase separation plays crucial roles in both sustaining cellular function and perpetuating disease states. Despite extensive studies, our understanding of this process is hindered by low solubility of phase-separating proteins. One example of this is f...
Inter-domain Flexibility of Human Ser/Arg-Rich Splicing Factor 1 Allows Variable Spacer Length in Cognate RNA's Bipartite Motifs.
Publication Type: Academic Journal
Source(s): Biochemistry [Biochemistry] 2022 Dec 20; Vol. 61 (24), pp. 2922-2932. Date of Electronic Publication: 2022 Dec 01.
Abstract: Ser/Arg-rich splicing factor 1 (SRSF1 or ASF/SF2) is the prototypical member of SR proteins. SRSF1 binds to exonic splicing enhancers, which prompts inclusion of corresponding exons in the mature mRNA. The RNA-binding domain of SRSF1 consists of tandem...
Intrinsically disordered electronegative clusters improve stability and binding specificity of RNA-binding proteins.
Publication Type: Academic Journal
Source(s): The Journal of biological chemistry [J Biol Chem] 2021 Aug; Vol. 297 (2), pp. 100945. Date of Electronic Publication: 2021 Jul 09.
Abstract: RNA-binding proteins play crucial roles in various cellular functions and contain abundant disordered protein regions. The disordered regions in RNA-binding proteins are rich in repetitive sequences, such as poly-K/R, poly-N/Q, poly-A, and poly-G resid...
Amide additives improve RDC measurements in polyacrylamide.
Publication Type: Academic Journal
Source(s): Journal of biomolecular NMR [J Biomol NMR] 2020 Mar; Vol. 74 (2-3), pp. 119-124. Date of Electronic Publication: 2020 Feb 13.
Abstract: Residual dipolar couplings (RDCs) provide valuable NMR parameters that can be used for structural calculation and verification. Measuring RDCs requires aligning macromolecules using one of various types of alignment media. Of different alignment media ...
In vitro and in vivo characterization of pentaerythritol triacrylate-co-trimethylolpropane nanocomposite scaffolds as potential bone augments and grafts.
Publication Type: Academic Journal
Source(s): Tissue engineering. Part A [Tissue Eng Part A] 2015 Jan; Vol. 21 (1-2), pp. 320-31. Date of Electronic Publication: 2014 Sep 19.
Abstract: A thiol-acrylate-based copolymer synthesized via an amine-catalyzed Michael addition was studied in vitro and in vivo to assess its potential as an in situ polymerizing graft or augment in bone defect repair. The blends of hydroxyapatite (HA) with pent...