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CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Abstract: A hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of ALS and FTD. Here, the authors demonstrate CRISPR/Cas9 excision of the expansion results in a rescue of disease mechanisms in vivo and in vitro.
Getting Recovery Right After Neck Dissection (GRRAND-F): Mixed-methods feasibility study to design a pragmatic randomised controlled trial
Publication Type: Academic Journal
Source(s): Frontiers in Oncology, Vol 13 (2023)
Abstract: ObjectiveTo determine the feasibility of a randomised controlled trial to estimate the effectiveness and cost-effectiveness of a rehabilitation intervention following neck dissection (ND) after head and neck cancer (HNC).DesignTwo-arm, open, pragmatic,...
Near-Peer Teaching in Radiology Symposia: A Success Story in Residents as Teachers
Publication Type: Academic Journal
Source(s): Journal of Medical Education and Curricular Development, Vol 10 (2023)
Abstract: INTRODUCTION Peer learning and near-peer teaching have been described in many specialties, less so in Radiology. We present near-peer teaching whereby residents present a series of didactic sessions at the course outset in the form of “symposia” and pe...
Lung recovery from DNA damage induced by graphene oxide is dependent on size, dose and inflammation profile
Publication Type: Academic Journal
Source(s): Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-21 (2022)
Abstract: Abstract Background A key aspect of any new material safety assessment is the evaluation of their in vivo genotoxicity. Graphene oxide (GO) has been studied for many promising applications, but there are remaining concerns about its safety profile, esp...
Patient and physiotherapist perceptions of the Getting Recovery Right After Neck Dissection (GRRAND) rehabilitation intervention: a qualitative interview study embedded within a feasibility trial
Publication Type: Academic Journal
Source(s): BMJ Open, Vol 12, Iss 11 (2022)
Abstract: Objective The Getting Recovery Right After Neck Dissection (GRRAND) intervention is a physiotherapy programme for patients with head and neck cancer who have undergone neck dissection. The aim of this qualitative study was to understand if the interven...
Inter-arm blood pressure difference and cardiovascular risk estimation in primary care: a pilot study
Publication Type: Academic Journal
Source(s): BJGP Open, Vol 6, Iss 3 (2022)
Abstract: Background: Systolic inter-arm differences (IAD) in blood pressure (BP) contribute independently to cardiovascular risk estimates. This can be used to refine predicted risk and guide personalised interventions. Aim: To model the effect of accounting fo...
Clinical management of community-acquired meningitis in adults in the UK and Ireland in 2017: a retrospective cohort study on behalf of the National Infection Trainees Collaborative for Audit and Research (NITCAR)
Publication Type: Academic Journal
Source(s): BMJ Open, Vol 12, Iss 7 (2022)
Abstract: Objectives To assess practice in the care of adults with suspected community-acquired bacterial meningitis in the UK and Ireland.Design Retrospective cohort study.Setting 64 UK and Irish hospitals.Participants 1471 adults with community-acquired mening...
A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract: It is unknown why infant acute lymphoblastic leukemia (ALL) produced by MLL rearrangements leads to worse outcomes than childhood ALL. Here the authors develop a CRISPR-Cas9-induced human xenograft model of MLL-AF4 infant-ALL that faithfully replicates...
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Abstract: Genome wide association studies in cancer are used to understand the heritable genetic contribution to disease risk. Here, the authors perform a genome wide association study in European patients with acute myeloid leukemia and identify loci associated...
Randomised controlled trial of a behaviour change physiotherapy intervention to increase physical activity following hip and knee replacement: the PEP-TALK trial
Publication Type: Academic Journal
Source(s): BMJ Open, Vol 12, Iss 5 (2022)
Abstract: Objective To test the effectiveness of a behaviour change physiotherapy intervention to increase physical activity compared with usual rehabilitation after total hip replacement (THR) or total knee replacement (TKR).Design Multicentre, pragmatic, two-a...