Advanced Search Results For "Fredrick, Laura D."
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Molecular screening reveals non-uniform malaria transmission in western Kenya and absence of Rickettsia africae and selected arboviruses in hospital patients
Publication Type: Academic Journal
Source(s): Malaria Journal, Vol 21, Iss 1, Pp 1-12 (2022)
Abstract: Abstract Background In sub-Saharan Africa, malaria is the common diagnosis for febrile illness and related clinical features, resulting in the under-diagnosis of other aetiologies, such as arboviruses and Rickettsia. While these may not be significant ...
Effect of a one-time financial incentive on linkage to chronic hypertension care in Kenya and Uganda: A randomized controlled trial.
Publication Type: Academic Journal
Source(s): PLoS ONE, Vol 17, Iss 11, p e0277312 (2022)
Abstract: BackgroundFewer than 10% of people with hypertension in sub-Saharan Africa are diagnosed, linked to care, and achieve hypertension control. We hypothesized that a one-time financial incentive and phone call reminder for missed appointments would increa...
Effect of a patient-centered hypertension delivery strategy on all-cause mortality: Secondary analysis of SEARCH, a community-randomized trial in rural Kenya and Uganda.
Publication Type: Academic Journal
Source(s): PLoS Medicine, Vol 18, Iss 9, p e1003803 (2021)
Abstract: BackgroundHypertension treatment reduces morbidity and mortality yet has not been broadly implemented in many low-resource settings, including sub-Saharan Africa (SSA). We hypothesized that a patient-centered integrated chronic disease model that inclu...
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Abstract: Prostate cancer (PrCa) involves a large heritable genetic component. Here, the authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with po...
The Scleroderma Patient-Centered Intervention Network Self-Management Program: Protocol for a Randomized Feasibility Trial
Publication Type: Academic Journal
Source(s): JMIR Research Protocols, Vol 9, Iss 4, p e16799 (2020)
Abstract: BackgroundSystemic sclerosis (SSc), or scleroderma, is a rare disease that often results in significant disruptions to activities of daily living and can negatively affect physical and psychological well-being. Because there is no known cure, SSc treat...
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Abstract: It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosom...
Genetic and Physical Localization of the Soybean Rpg1-b Disease Resistance Gene Reveals a Complex Locus Containing Several Tightly Linked Families of NBS-LRR Genes
Publication Type: Academic Journal
Source(s): Molecular Plant-Microbe Interactions, Vol 16, Iss 9, Pp 817-826 (2003)
Abstract: Alleles or tightly linked genes at the soybean (Glycine max L. Merr.) Rpg1 locus confer resistance to strains of Pseudomonas syringae pv. glycinea that express the avirulence genes avrB or avrRpm1. We have previously mapped Rpg1-b (the gene specific fo...
A randomized pilot trial of a moderate carbohydrate diet compared to a very low carbohydrate diet in overweight or obese individuals with type 2 diabetes mellitus or prediabetes.
Publication Type: Academic Journal
Source(s): PLoS ONE, Vol 9, Iss 4, p e91027 (2014)
Abstract: We compared the effects of two diets on glycated hemoglobin (HbA1c) and other health-related outcomes in overweight or obese adults with type 2 diabetes or prediabetes (HbA1c>6%). We randomized participants to either a medium carbohydrate, low fat, cal...
MicroRNA related polymorphisms and breast cancer risk.
Publication Type: Academic Journal
Source(s): PLoS ONE, Vol 9, Iss 11, p e109973 (2014)
Abstract: Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or in the miRNA binding sites may affect the miRNA dependent gene expression regulation, which has been implicated in various cancers, including breast cancer, and ...
A genome-wide 'pleiotropy scan' does not identify new susceptibility loci for estrogen receptor negative breast cancer.
Publication Type: Academic Journal
Source(s): PLoS ONE, Vol 9, Iss 2, p e85955 (2014)
Abstract: Approximately 15-30% of all breast cancer tumors are estrogen receptor negative (ER-). Compared with ER-positive (ER+) disease they have an earlier age at onset and worse prognosis. Despite the vast number of risk variants identified for numerous cance...