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Advanced Search Results For "Free, David"

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 "Free, David"
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Improved data linkage in the Extended Cohort for E-health, Environment and DNA (EXCEED) study through an electronic informed consent (eConsent) and recruitment management system.

Publication Type:Academic Journal

Source(s):International Journal of Population Data Science, Vol 7, Iss 3 (2022)

Abstract:Objectives The complexities of the informed consent process for participating in cohort-based medical studies are well-recognised, and the pandemic presented specific challenges related to this. Our response in EXCEED was to build and deploy a local se...

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Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine

Publication Type:Academic Journal

Source(s):iScience, Vol 25, Iss 8, Pp 104771- (2022)

Abstract:Summary: Bromocriptine is approved as a diabetes therapy, yet its therapeutic mechanisms remain unclear. Though bromocriptine’s actions have been mainly attributed to the stimulation of brain dopamine D2 receptors (D2R), bromocriptine also targets the ...

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TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Abstract:The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK...

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A qualitative study of stakeholder views on the use of a digital app for supported self-management in early intervention services for psychosis

Publication Type:Academic Journal

Source(s):BMC Psychiatry, Vol 21, Iss 1, Pp 1-12 (2021)

Abstract:Abstract Background Digital tools such as Smartphones have the potential to increase access to mental health support including self-management interventions for individuals with psychosis, and ultimately to improve outcomes. Self-management strategies,...

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Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors

Publication Type:Academic Journal

Source(s):Translational Psychiatry, Vol 11, Iss 1, Pp 1-18 (2021)

Abstract:Abstract Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators of metabolism. Pancreatic catecholamine signaling has also been increasingly implic...

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United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): a retrospective cohort study using linked routinely collected data, study protocol

Publication Type:Academic Journal

Source(s):BMJ Open, Vol 11, Iss 6 (2021)

Abstract:Introduction COVID-19 has spread rapidly worldwide, causing significant morbidity and mortality. People from ethnic minorities, particularly those working in healthcare settings, have been disproportionately affected. Current evidence of the associatio...

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Modified percutaneous tracheostomy in patients with COVID-19

Publication Type:Academic Journal

Source(s):Trauma Surgery & Acute Care Open, Vol 5, Iss 1 (2020)

Abstract:Background Patients hospitalized with COVID-19 are at risk of developing hypoxic respiratory failure and often require prolonged mechanical ventilation. Indication and timing to perform tracheostomy is controversial in patients with COVID-19.Methods Th...

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Inter-centre variability of CT-based stopping-power prediction in particle therapy: Survey-based evaluation

Publication Type:Academic Journal

Source(s):Physics and Imaging in Radiation Oncology, Vol 6, Iss , Pp 25-30 (2018)

Abstract:Background and purpose: Stopping-power ratios (SPRs) are used in particle therapy to calculate particle range in patients. The heuristic CT-to-SPR conversion (Hounsfield Look-Up-Table, HLUT), needed for treatment planning, depends on CT-scan and recons...

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