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Advanced Search Results For "GILES, FRANK"

1 - 10 of 1,583 results for
 "GILES, FRANK"
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Association of body mass index with outcomes in patients with newly diagnosed atrial fibrillation: GARFIELD-AF

Publication Type:Academic Journal

Source(s):Open Heart, Vol 9, Iss 2 (2022)

Abstract:Objective While greater body mass index (BMI) is associated with increased risk of developing atrial fibrillation (AF), the impact of BMI on outcomes in newly diagnosed AF is unclear. We examine the influence of BMI on outcomes and whether this is modi...

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β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery

Publication Type:Academic Journal

Source(s):Clinical and Translational Science, Vol 15, Iss 3, Pp 619-625 (2022)

Abstract:Abstract Junctional ectopic tachycardia (JET) is a potentially life‐threatening postoperative arrhythmia in children with specific congenital heart defects and can contribute significantly to postoperative morbidity for at‐risk populations. In adults, ...

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Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19

Publication Type:Academic Journal

Source(s):Frontiers in Immunology, Vol 13 (2022)

Abstract:Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality in patients infected with SARS-CoV-2. Severe COVID-19 has been associated with hyperinflammat...

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Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity

Publication Type:Academic Journal

Source(s):Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract:Abstract Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype o...

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Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

Abstract:Associations between of omega-3 fatty acids and mortality are not clear. Here the authors report that, based on a pooled analysis of 17 prospective cohort studies, higher blood omega-3 fatty acid levels correlate with lower risk of all-cause mortality.

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The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Publication Type:Academic Journal

Source(s):iScience, Vol 24, Iss 11, Pp 103353- (2021)

Abstract:Summary: We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of reco...

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Functional brain defects in a mouse model of a chromosomal t(1;11) translocation that disrupts DISC1 and confers increased risk of psychiatric illness

Publication Type:Academic Journal

Source(s):Translational Psychiatry, Vol 11, Iss 1, Pp 1-16 (2021)

Abstract:Abstract A balanced t(1;11) translocation that directly disrupts DISC1 is linked to schizophrenia and affective disorders. We previously showed that a mutant mouse, named Der1, recapitulates the effect of the translocation upon DISC1 expression. Here, ...

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Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

Abstract:A polygenic hazard score (PHS1) improves prostate cancer screening accuracy in European patients. Here, the authors test the performance of a version compatible with OncoArray genotypes (PHS2) in a multi-ethnic dataset and find that it risk-stratifies ...

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Open data from the first and second observing runs of Advanced LIGO and Advanced Virgo

Publication Type:Academic Journal

Source(s):SoftwareX, Vol 13, Iss , Pp 100658- (2021)

Abstract:Advanced LIGO and Advanced Virgo are monitoring the sky and collecting gravitational-wave strain data with sufficient sensitivity to detect signals routinely. In this paper we describe the data recorded by these instruments during their first and secon...

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PHarmacist Avoidance or Reductions in Medical Costs in Patients Presenting the EMergency Department: PHARM-EM Study

Publication Type:Academic Journal

Source(s):Critical Care Explorations, Vol 3, Iss 4, p e0406 (2021)

Abstract:Objectives:. To comprehensively classify interventions performed by emergency medicine clinical pharmacists and quantify cost avoidance generated through their accepted interventions. Design:. A multicenter, prospective, observational study was perform...

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