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Advanced Search Results For "GILL, STEPHEN"

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Gambling, fast food and alcohol sponsorship in elite sport – perspectives from Australian sporting fans

Publication Type: Academic Journal

Source(s): BMC Public Health, Vol 22, Iss 1, Pp 1-10 (2022)

Abstract: Abstract Background Public health bodies in Australia remain concerned about marketing of unhealthy commodities; namely unhealthy food, alcohol and gambling products. Children are particularly susceptible to the influence of unhealthy commodity marketi...

The influence of adjuvant chemotherapy dose intensity on overall survival in resected colon cancer: a multicentered retrospective analysis

Publication Type: Academic Journal

Source(s): BMC Cancer, Vol 22, Iss 1, Pp 1-6 (2022)

Abstract: Abstract Background Colorectal cancer remains the second leading cause of cancer death in North America. Fluorouracil and oxaliplatin based adjuvant chemotherapy for resected colon cancer (CC) reduces cancer recurrence, but also causes significant toxi...

The role of staging laparoscopy in pancreatic adenocarcinoma and its effect on patients’ survival

Publication Type: Academic Journal

Source(s): World Journal of Surgical Oncology, Vol 20, Iss 1, Pp 1-7 (2022)

Abstract: Abstract Background Prompt and accurate staging of pancreatic cancer is essential to distinguish patients to benefit from resection with curative intent and those with unresectable disease. A staging laparoscopy is used preoperatively to identify macro...

Sendai F/HN pseudotyped lentiviral vector transduces human ciliated and non-ciliated airway cells using α 2,3 sialylated receptors

Publication Type: Academic Journal

Source(s): Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 239-252 (2022)

Abstract: A lentiviral vector (LV) pseudotype derived from the fusion (F) and hemagglutinin-neuraminidase (HN) glycoproteins of a murine respirovirus (Sendai virus) facilitates efficient targeting of murine lung in vivo. Since targeting of the human lung will de...

Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies

Publication Type: Academic Journal

Source(s): Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 625-642 (2022)

Abstract: Tau is a microtubule-associated protein (MAPT, tau) implicated in the pathogenesis of tauopathies, a spectrum of neurodegenerative disorders characterized by accumulation of hyperphosphorylated, aggregated tau. Because tau pathology can be distinct acr...

In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

Abstract: Standard assessment of immune infiltration of biopsies is not sufficient to accurately predict response to immunotherapy. Here, the authors show that reflectance confocal microscopy can be used to quantify dynamic vasculature and inflammatory features ...


The amyloid imaging for the prevention of Alzheimer's disease consortium: A European collaboration with global impact

Publication Type: Academic Journal

Source(s): Frontiers in Neurology, Vol 13 (2023)

Abstract: BackgroundAmyloid-β (Aβ) accumulation is considered the earliest pathological change in Alzheimer's disease (AD). The Amyloid Imaging to Prevent Alzheimer's Disease (AMYPAD) consortium is a collaborative European framework across European Federation of...

Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism

Publication Type: Academic Journal

Source(s): iScience, Vol 26, Iss 1, Pp 105911- (2023)

Abstract: Summary: Placental hormones orchestrate maternal metabolic adaptations to support pregnancy. We hypothesized that placental ER stress, which characterizes early-onset pre-eclampsia (ePE), compromises glycosylation, reducing hormone bioactivity and thes...

Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups

Publication Type: Academic Journal

Source(s): BMC Medicine, Vol 20, Iss 1, Pp 1-7 (2022)

Abstract: Abstract Background Interleukin 6 (IL-6) signaling is being investigated as a therapeutic target for atherosclerotic cardiovascular disease (CVD). While changes in circulating high-sensitivity C-reactive protein (hsCRP) are used as a marker of IL-6 sig...

The CCTG PA.7 phase II trial of gemcitabine and nab-paclitaxel with or without durvalumab and tremelimumab as initial therapy in metastatic pancreatic ductal adenocarcinoma

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)

Abstract: Metastatic pancreatic ductal adenocarcinoma (mPDAC) has limited therapeutic options and is associated with a poor prognosis. Here the authors report the results of a randomized phase II trial showing that combining checkpoint inhibitors (durvalumab and...