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 "George S"
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Effects of lifestyle physical activity and sedentary behaviour interventions on disease activity and patient- and clinician- important health outcomes in rheumatoid arthritis: a systematic review with meta-analysis

Publication Type: Academic Journal

Source(s): BMC Rheumatology, Vol 7, Iss 1, Pp 1-26 (2023)

Abstract: Abstract Background Lifestyle physical activity (PA) is defined as any type of PA undertaken as part of daily life. It can include engagement in activities of daily living (i.e., household chores, gardening, walking to work), incidental PA, walking and...

High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons

Publication Type: Academic Journal

Source(s): SLAS Discovery, Vol 28, Iss 6, Pp 275-283 (2023)

Abstract: Human induced pluripotent stem cell (iPSC)-derived neurons are being increasingly used for high content imaging and screening. However, iPSC-derived neuronal differentiation and maturation is time-intensive, often requiring >8 weeks. Unfortunately, the...

Inceptor as a regulator of brain insulin sensitivity

Publication Type: Academic Journal

Source(s): Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Abstract: Abstract While historically viewed as an insulin insensitive organ, it is now accepted that insulin has a role in brain physiology. Changes in brain insulin and IGF1 signaling have been associated with neurological diseases, however the molecular facto...


Computational analysis of peripheral blood smears detects disease-associated cytomorphologies

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract: Abstract Many hematological diseases are characterized by altered abundance and morphology of blood cells and their progenitors. Myelodysplastic syndromes (MDS), for example, are a group of blood cancers characterised by cytopenias, dysplasia of hemato...


Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Abstract: Abstract Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukaemia (AML) and is often driven by metabolic adaptations which are therapeutically actionable. Here we identify inhibition of mannose-6-phosphate...


Athletes with mild post-COVID-19 symptoms experience increased respiratory and metabolic demands: Α cross-sectional study

Publication Type: Academic Journal

Source(s): Sports Medicine and Health Science, Vol 5, Iss 2, Pp 106-111 (2023)

Abstract: Coronavirus Disease 2019 (COVID-19) has significantly affected different physiological systems, with a potentially profound effect on athletic performance. However, to date, such an effect has been neither addressed nor investigated. Therefore, the aim...

Cooperative NF-κB and Notch1 signaling promotes macrophage-mediated MenaINV expression in breast cancer

Publication Type: Academic Journal

Source(s): Breast Cancer Research, Vol 25, Iss 1, Pp 1-18 (2023)

Abstract: Abstract Metastasis is a multistep process that leads to the formation of clinically detectable tumor foci at distant organs and frequently to patient demise. Only a subpopulation of breast cancer cells within the primary tumor can disseminate systemic...

Mixed reality visualization in shoulder arthroplasty: is it better than traditional preoperative planning software?

Publication Type: Academic Journal

Source(s): Clinics in Shoulder and Elbow, Vol 26, Iss 2, Pp 117-125 (2023)

Abstract: Background Preoperative traditional software planning (TSP) is a method used to assist surgeons with implant selection and glenoid guide-pin insertion in shoulder arthroplasty. Mixed reality (MR) is a new technology that uses digital holograms of the p...

A Prospective Cohort Study (OUTSTRIP-COVID) on Functional and Spirometry Outcomes in COVID-19 ICU Survivors at 3 Months

Publication Type: Academic Journal

Source(s): International Journal of General Medicine, Vol Volume 16, Pp 2633-2642 (2023)

Abstract: Merlin Thomas,1,2 Tasleem Raza,1– 3 Mansoor Hameed,1,2 Rohit Sharma,4 Rajalekshmi Maheswari Rajagopal,5 Aisha Hussain O Al Adab,1,2 Mushtaq Ahmad,1,2 Saibu George,2,3 Mousa Hussein,1 Jaweria Akram,3 Mohamed Izham Mohamed Ibrahim,6 Ali Ait Hssain,2,3 Mu...

Analysis of regional features of the tibial plateau fractures in the Rostov region

Publication Type: Academic Journal

Source(s): Travmatologiâ i Ortopediâ Rossii, Vol 29, Iss 2, Pp 74-87 (2023)

Abstract: Background. The prevalence of tibial plateau fractures reaches 51.7 per 100,000 population per year, accounting for approximately 1% of all fractures, and is associated with the development of post-traumatic knee osteoarthritis in 25-45% of cases. T...