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A Brief Introduction to Chemical Reaction Optimization.
Publication Type: Academic Journal
Source(s): Chemical reviews [Chem Rev] 2023 Feb 23. Date of Electronic Publication: 2023 Feb 23.
Abstract: From the start of a synthetic chemist's training, experiments are conducted based on recipes from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist to develop practical skills and some chemical intuition. This proce...
Role of Half-of-Sites Reactivity and Inter-Subunit Communications in DAHP Synthase Catalysis and Regulation.
Publication Type: Academic Journal
Source(s): Biochemistry [Biochemistry] 2022 Oct 18; Vol. 61 (20), pp. 2229-2240. Date of Electronic Publication: 2022 Oct 05.
Abstract: α-Carboxyketose synthases, including 3-deoxy-d- arabino heptulosonate 7-phosphate synthase (DAHPS), are long-standing targets for inhibition. They are challenging targets to create tight-binding inhibitors against, and inhibitors often display half-of-...
Prolonged COVID-19 symptom duration in people with systemic autoimmune rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey.
Publication Type: Academic Journal
Source(s): RMD open [RMD Open] 2022 Sep; Vol. 8 (2).
Abstract: Objective: We investigated prolonged COVID-19 symptom duration, defined as lasting 28 days or longer, among people with systemic autoimmune rheumatic diseases (SARDs).Methods: We analysed data from the COVID-19 Global Rheumatology Alliance Vaccine Surv...
COVID-19 therapeutics: Challenges and directions for the future.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Apr 12; Vol. 119 (15), pp. e2119893119. Date of Electronic Publication: 2022 Apr 06.
Abstract: The emergence of SARS-CoV-2 triggering the COVID-19 pandemic ranks as arguably the greatest medical emergency of the last century. COVID-19 has highlighted health disparities both within and between countries and will leave a lasting impact on global s...
Zenker's peroral endoscopic myotomy, or flexible or rigid septotomy for Zenker's diverticulum: a multicenter retrospective comparison.
Publication Type: Academic Journal
Source(s): Endoscopy [Endoscopy] 2022 Apr; Vol. 54 (4), pp. 345-351. Date of Electronic Publication: 2021 Jul 01.
Abstract: Background: Treatment of Zenker's diverticulum has evolved from open surgery to endoscopic techniques, including flexible and rigid endoscopic septotomy, and more recently, peroral endoscopic myotomy (Z-POEM). This study compared the effectiveness of f...
An Inhibitor-in-Pieces Approach to DAHP Synthase Inhibition: Potent Enzyme and Bacterial Growth Inhibition.
Publication Type: Academic Journal
Source(s): ACS infectious diseases [ACS Infect Dis] 2021 Dec 10; Vol. 7 (12), pp. 3292-3302. Date of Electronic Publication: 2021 Nov 11.
Abstract: 3-Deoxy-d- arabino heptulosonate-7-phosphate (DAHP) synthase catalyzes the first step in the shikimate biosynthetic pathway and is an antimicrobial target. We used an inhibitor-in-pieces approach, based on the previously reported inhibitor DAHP oxime, ...
GABA A Alpha 2,3 Modulation Improves Select Phenotypes in a Mouse Model of Fragile X Syndrome.
Publication Type: Academic Journal
Source(s): Frontiers in psychiatry [Front Psychiatry] 2021 May 21; Vol. 12, pp. 678090. Date of Electronic Publication: 2021 May 21 (Print Publication: 2021).
Abstract: Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability. FXS is caused by functional loss of the Fragile X Protein (FXP), also known as Fragile X Mental Retardation Protein (FMRP). In humans and animal models, loss of FXP...
Identification of Bioactive SNM1A Inhibitors.
Publication Type: Academic Journal
Source(s): ACS omega [ACS Omega] 2021 Mar 31; Vol. 6 (14), pp. 9352-9361. Date of Electronic Publication: 2021 Mar 31 (Print Publication: 2021).
Abstract: SNM1A is a nuclease required to repair DNA interstrand cross-links (ICLs) caused by some anticancer compounds, including cisplatin. Unlike other nucleases involved in ICL repair, SNM1A is not needed to restore other forms of DNA damage. As such, SNM1A ...
The Helminth Parasite Heligmosomoides polygyrus Attenuates EAE in an IL-4Rα-Dependent Manner.
Publication Type: Academic Journal
Source(s): Frontiers in immunology [Front Immunol] 2020 Sep 29; Vol. 11, pp. 1830. Date of Electronic Publication: 2020 Sep 29 (Print Publication: 2020).
Abstract: Helminth parasites are effective in biasing Th2 immunity and inducing regulatory pathways that minimize excessive inflammation within their hosts, thus allowing chronic infection to occur whilst also suppressing bystander atopic or autoimmune diseases....
The Escherichia coli MarA protein regulates the ycgZ-ymgABC operon to inhibit biofilm formation.
Publication Type: Academic Journal
Source(s): Molecular microbiology [Mol Microbiol] 2019 Nov; Vol. 112 (5), pp. 1609-1625. Date of Electronic Publication: 2019 Sep 29.
Abstract: The Escherichia coli marRAB operon is a paradigm for chromosomally encoded antibiotic resistance. The operon exerts its effect via an encoded transcription factor called MarA that modulates efflux pump and porin expression. In this work, we show that M...