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Advanced Search Results For "Grant, Ruth W."

1 - 10 of 293 results for
 "Grant, Ruth W."
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Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Publication Type:Academic Journal

Source(s):Communications Biology, Vol 5, Iss 1, Pp 1-20 (2022)

Abstract:A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease.

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The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Publication Type:Academic Journal

Source(s):iScience, Vol 24, Iss 11, Pp 103353- (2021)

Abstract:Summary: We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of reco...

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Inflammatory Biomarkers Are Associated With a Decline in Functional Status at Discharge in Children With Acute Respiratory Failure: An Exploratory Analysis

Publication Type:Academic Journal

Source(s):Critical Care Explorations, Vol 3, Iss 7, p e0467 (2021)

Abstract:OBJECTIVES:. To evaluate the link between early acute respiratory failure and functional morbidity in survivors using the plasma biomarkers interleukin-8, interleukin-1 receptor antagonist, thrombomodulin, and plasminogen activator inhibitor-1. We hypo...

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Associations of autozygosity with a broad range of human phenotypes

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Abstract:Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associ...

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Nonlinear Z‐score modeling for improved detection of cognitive abnormality

Publication Type:Academic Journal

Source(s):Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 797-808 (2019)

Abstract:Abstract Introduction Conventional Z‐scores are generated by subtracting the mean and dividing by the standard deviation. More recent methods linearly correct for age, sex, and education, so that these “adjusted” Z‐scores better represent whether an in...

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Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Abstract:Estimated glomerular filtration rate (eGFR) is a measure of kidney function used to define chronic kidney disease. Here, Morris et al. perform trans-ethnic genome-wide meta-analyses for eGFR in 312,468 individuals and identify novel loci and downstream...

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CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Abstract:Individual SNPs have small effects on anthropometric traits, yet the impact of CNVs has remained largely unknown. Here, Kutalik and co-workers perform a large-scale genome-wide meta-analysis of structural variation and find rare CNVs associated with he...

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