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Advanced Search Results For "HOROWITZ, STEVEN J."

1 - 10 of 958 results for
 "HOROWITZ, STEVEN J."
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Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Abstract: Osteoporosis GWAS faces two challenges, causal gene discovery and a lack of phenotypic diversity. Here, the authors use the Diversity Outbred mouse population to inform human GWAS using networks and map genetic loci for 55 bone traits, identifying new ...

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Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network

Publication Type: Academic Journal

Source(s): Lupus Science and Medicine, Vol 8, Iss 1 (2021)

Abstract: Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating ide...

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Correction to: The NYCKidSeq project: study protocol for a randomized controlled trial incorporating genomics into the clinical care of diverse New York City children

Publication Type: Academic Journal

Source(s): Trials, Vol 22, Iss 1, Pp 1-6 (2021)

Abstract: An amendment to this paper has been published and can be accessed via the original article.

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The NYCKidSeq project: study protocol for a randomized controlled trial incorporating genomics into the clinical care of diverse New York City children

Publication Type: Academic Journal

Source(s): Trials, Vol 22, Iss 1, Pp 1-14 (2021)

Abstract: Abstract Background Increasingly, genomics is informing clinical practice, but challenges remain for medical professionals lacking genetics expertise, and in access to and clinical utility of genomic testing for minority and underrepresented population...

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Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli

Publication Type: Academic Journal

Source(s): Respiratory Research, Vol 19, Iss 1, Pp 1-12 (2018)

Abstract: Abstract Background Fibroblast apoptosis is a critical component of normal repair and the acquisition of an apoptosis-resistant phenotype contributes to the pathogenesis of fibrotic repair. Fibroblasts from fibrotic lungs of humans and mice demonstrate...

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Genomic landscape of high-grade meningiomas

Publication Type: Academic Journal

Source(s): npj Genomic Medicine, Vol 2, Iss 1, Pp 1-14 (2017)

Abstract: Brain tumors: uncovering genomic disruption in meningiomas Meningiomas, which arise from the tissue surrounding the brain and spinal cord, are the most common primary brain tumor in adults. The majority of these are slow-growing and amenable to surgica...

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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 313-326.e5 (2018)

Abstract: Summary: Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic sub...

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Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 227-238.e3 (2018)

Abstract: Summary: Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% ...

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Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 181-193.e7 (2018)

Abstract: Summary: Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images f...

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